An overview of available antimalarials: discovery, mode of action and drug resistance
YQ Tang, Q Ye, H Huang… - Current Molecular …, 2020 - ingentaconnect.com
Malaria is one of the three most deadly infectious diseases in the world and seriously
endangers human health and life. To reduce the public health burden of this disease …
endangers human health and life. To reduce the public health burden of this disease …
Review of the current landscape of the potential of nanotechnology for future malaria diagnosis, treatment, and vaccination strategies
A Guasch-Girbau, X Fernàndez-Busquets - Pharmaceutics, 2021 - mdpi.com
Malaria eradication has for decades been on the global health agenda, but the causative
agents of the disease, several species of the protist parasite Plasmodium, have evolved …
agents of the disease, several species of the protist parasite Plasmodium, have evolved …
Targeting the liver stage of malaria parasites: a yet unmet goal
Malaria remains one of the world's most prevalent tropical diseases because of its high
mortality and morbidity burden, as well as its economic and social impacts on the …
mortality and morbidity burden, as well as its economic and social impacts on the …
Application of pharmacogenomics to malaria: a holistic approach for successful chemotherapy
RK Mehlotra, CN Henry-Halldin… - …, 2009 - Taylor & Francis
Drug resistance in malaria jeopardizes the most elementary objectives of malaria control–
reducing suffering and eliminating mortality. An important, and so far the only known …
reducing suffering and eliminating mortality. An important, and so far the only known …
Genomics and systems biology in malaria drug discovery.
A disadvantage of using target-based drug discovery in the search for new antimalarials is
that predicting which targets will be essential for parasite growth in mammalian hosts is often …
that predicting which targets will be essential for parasite growth in mammalian hosts is often …
Chemoproteomics for Plasmodium Parasite Drug Target Discovery
KY Lu, CR Mansfield, MC Fitzgerald… - …, 2021 - Wiley Online Library
Emerging Plasmodium parasite drug resistance is threatening progress towards malaria
control and elimination. While recent efforts in cell‐based, high‐throughput drug screening …
control and elimination. While recent efforts in cell‐based, high‐throughput drug screening …
The global pipeline of new medicines for the control and elimination of malaria
MP Anthony, JN Burrows, S Duparc, J JMoehrle… - Malaria journal, 2012 - Springer
Over the past decade, there has been a transformation in the portfolio of medicines to
combat malaria. New fixed-dose artemisinin combination therapy is available, with four …
combat malaria. New fixed-dose artemisinin combination therapy is available, with four …
[HTML][HTML] New interventions for malaria: mining the human and parasite genomes
F Ntoumi, DP Kwiatkowski, M Diakité… - … and Defeating the …, 2007 - ncbi.nlm.nih.gov
Malaria has been the greatest scourge of humankind for many millennia, and as a
consequence has had more impact than any other pathogen in shaping the human genome …
consequence has had more impact than any other pathogen in shaping the human genome …
[HTML][HTML] Current and emerging target identification methods for novel antimalarials
New antimalarial compounds with novel mechanisms of action are urgently needed to
combat the recent rise in antimalarial drug resistance. Phenotypic high-throughput screens …
combat the recent rise in antimalarial drug resistance. Phenotypic high-throughput screens …
PlasmoDB: exploring genomics and post-genomics data of the malaria parasite, Plasmodium falciparum
MJ Fraunholz, DS Roos - Redox report, 2003 - Taylor & Francis
The recent completion of the genome sequence of Plasmodium falciparum 3D7 provides the
foundation for genome-wide analysis of the parasite. In addition to DNA and gene sequence …
foundation for genome-wide analysis of the parasite. In addition to DNA and gene sequence …