Malaria is one of the three most deadly infectious diseases in the world and seriously
endangers human health and life. To reduce the public health burden of this disease …

Malaria eradication has for decades been on the global health agenda, but the causative
agents of the disease, several species of the protist parasite Plasmodium, have evolved …

Malaria remains one of the world's most prevalent tropical diseases because of its high
mortality and morbidity burden, as well as its economic and social impacts on the …

Drug resistance in malaria jeopardizes the most elementary objectives of malaria control–
reducing suffering and eliminating mortality. An important, and so far the only known …

A disadvantage of using target-based drug discovery in the search for new antimalarials is
that predicting which targets will be essential for parasite growth in mammalian hosts is often …

Emerging Plasmodium parasite drug resistance is threatening progress towards malaria
control and elimination. While recent efforts in cell‐based, high‐throughput drug screening …

Over the past decade, there has been a transformation in the portfolio of medicines to
combat malaria. New fixed-dose artemisinin combination therapy is available, with four …

Malaria has been the greatest scourge of humankind for many millennia, and as a
consequence has had more impact than any other pathogen in shaping the human genome …

New antimalarial compounds with novel mechanisms of action are urgently needed to
combat the recent rise in antimalarial drug resistance. Phenotypic high-throughput screens …

The recent completion of the genome sequence of Plasmodium falciparum 3D7 provides the
foundation for genome-wide analysis of the parasite. In addition to DNA and gene sequence …