In recent years, the research agenda to tackle global morbidity and mortality from malaria
disease has shifted towards innovation, in the hope that efforts at the frontiers of scientific …

The major problem facing world research for new antimalarials lies in encountered
difficulties in the search for new promising paths. The past 20 years have witnessed a very …

There is a shift in antimalarial drug discovery from phenotypic screening toward target-
based approaches, as more potential drug targets are being validated in Plasmodium …

Several antimalarial drugs exist, but differences between life cycle stages among malaria
species pose challenges for developing more effective therapies. To understand the …

Malaria remains a major global health problem, with more than half of the world population
at risk of contracting the disease and nearly a million deaths each year. Here, we report the …

The emergence and spread of drug-resistant malaria parasites is a serious public health
problem in the tropical world. Malaria control has relied upon the traditional quinoline …

The organization and mining of malaria genomic and post-genomic data is important to
significantly increase the knowledge of the biology of its causative agents, and is motivated …

The prevalence of resistance to known antimalarial drugs has resulted in the expansion of
antimalarial drug discovery efforts. Academic and nonprofit institutions are partnering with …

Malaria is one of the most prevalent and devastating infectious diseases of our time. Yet,
unfortunately, apart from artemisinin combination therapies there are relatively few effective …

Open-access drug discovery provides a substantial resource for diseases primarily affecting
the poor and disadvantaged. The open-access Pathogen Box collection is comprised of …