Although numerous studies have uncovered the molecular mechanisms regulating
pancreas development, it remains to be clarified how β-cells arise from progenitors and how …

Aims/hypothesis Glucagon-expressing pancreatic alpha cells have attracted much attention
for their plasticity to transdifferentiate into insulin-producing beta cells; however, it remains …

Aims/hypothesis While pancreatic beta cells have been shown to originate from endocrine
progenitors in ductal regions, it remains unclear precisely where beta cells emerge from and …

Diabetes is a chronic and incurable disease, which results from absolute or relative insulin
insufficiency. Therefore, pancreatic beta cells, which are the only type of cell that expresses …

Newly differentiated pancreatic β cells lack proper insulin secretion profiles of mature
functional β cells. The global gene expression differences between paired immature and …

Research on the postnatal development of pancreatic beta-cells has become an important
subject in recent years. Understanding the mechanisms that govern beta-cell postnatal …

Cellular progenitors remain poorly characterized in many adult tissues, limited in part by the
lack of unbiased techniques to identify progenitors and their progeny. To address this …

Pancreatic β and α cells play essential roles in maintaining glucose homeostasis. However,
the mechanisms by which these distinct cell populations are generated, expand, and mature …

The enigmatic process of β-cell maturation has significant implications for diabetes
pathogenesis, and potential diabetes therapies. This study examined the dynamics and …

The in vitro differentiation of insulin-producing beta-like cells can model aspects of human
pancreatic development. Here, we generate 95,308 single-cell transcriptomes and …