ABSTRACT HIV-1-specific cytotoxic T-lymphocytes (CTLs) with strong abilities to suppress
HIV-1 replication and recognize most circulating HIV-1 strains are candidates for effector T …

Background Development of AIDS vaccines for effective prevention of circulating HIV-1 is
required, but no trial has demonstrated definitive effects on the prevention. Several recent T …

Candidate human immunodeficiency virus type 1 (HIV-1) vaccines designed to elicit T-cell
immunity in HIV-1-uninfected persons are under investigation in phase I to III clinical trials …

Identification and characterization of CD8+ T cells effectively controlling HIV-1 variants are
necessary for the development of AIDS vaccines and for studies of AIDS pathogenesis …

The definition of immune correlates of protection in HIV-1 infection is pivotal to the design of
successful vaccine candidates and strategies. Although significant methodological and …

ABSTRACT Pol283-8-specific, HLA-B* 51: 01-restricted, cytotoxic T cells (CTLs) play a
critical role in the long-term control of HIV-1 infection. However, these CTLs select for the …

Substantial evidence argues that human immunodeficiency virus type 1 (HIV-1)-specific
CD4+ T cells play an important role in the control of HIV-1 replication in infected individuals …

Cytotoxic T lymphocytes that specifically lyse HIV-1-infected cells occur at uncommonly high
frequency in the blood of infected individuals. The CTL response is dominated by the …

Despite significant advancements in our understanding of HIV persistence and immunology,
long-term remission of HIV off antiretroviral therapy (ART) has not been achieved except in a …

A successful HIV vaccine will likely induce both humoral and cell-mediated immunity,
however, the enormous diversity of HIV has hampered the development of a vaccine that …