Although the cerebrovasculature is known to be exquisitely sensitive to CO2, there is no
consensus on whether the sympathetic nervous system plays a role in regulating …

We investigated the effect of baroreflex‐induced sympathetic activation, produced by lower
body negative pressure (LBNP) at− 40 mmHg, on cerebrovascular responsiveness to hyper …

Key points• Arterial CO2 serves as a mediator of cerebral blood flow, and its relative
influence on the regulation of cerebral blood flow is defined as cerebral CO2 reactivity.• …

New Findings What is the central question of this study? There is an interaction between the
regulatory systems of respiration and cerebral blood flow, because the mediator (CO2) is the …

Changes in the partial pressure of arterial CO2 (PaCO2) regulates cerebrovascular tone and
dynamic cerebral autoregulation (CA). Elevations in PaCO2 also increases autonomic …

The respiratory and cerebrovascular reactivity to changes in arterial Pco2 () is an important
mechanism that maintains CO2 or pH homeostasis in the brain. It remains unclear, however …

New Findings What is the central question of this study? Do differing magnitudes of
ventilation influence cerebrovascular CO2 reactivity and the cerebral blood flow response to …

The new two-breath CO2 method was employed to test the hypotheses that small alterations
in arterial Pco2 had an impact on the magnitude and dynamic response time of the CO2 …

Cerebrovascular CO2 reactivity (the change in cerebral blood flow per mm Hg change in
Pacoco2) is shown to be directly related to resting flow and inversely related to blood …

New Findings What is the central question of this study? In acute hypoxia, the reduction in
arterial CO2 tension due to the hypoxic ventilatory response (respiratory chemoreflex) …