Plk4 family kinases control centriole assembly. Plk4s target mother centrioles through an
interaction between their cryptic polo box (CPB) and acidic regions in the centriolar …

Centrosomes play an important role in various cellular processes, including spindle
formation and chromosome segregation. They are composed of two orthogonally arranged …

Centriole assembly initiates when Polo-like kinase 4 (Plk4) interacts with a centriole
“targeting-factor.” In Drosophila, Asterless/Asl (Cep152 in humans) fulfills the targeting role …

Polo-like kinase 4 (PLK4) is a key regulator of centriole biogenesis, but how PLK4 selects a
single site for procentriole assembly remains unclear. Using ultrastructure expansion …

Summary Polo-like kinase 4 (Plk4) is a key regulator of centriole duplication, but the
mechanism underlying its recruitment to mammalian centrioles is not understood. In flies …

Centrosomes are major microtubule-organizing centers composed of centrioles surrounded
by an extensive proteinacious layer called the pericentriolar material (PCM). In …

Centrioles are key microtubule polarity determinants. Centriole duplication is tightly
controlled to prevent cells from developing multipolar spindles, a situation that promotes …

Centriole duplication is a high-fidelity process driven by Polo-like kinase 4 (Plk4) and a few
conserved initiators. Dissecting how Plk4 and its receptors organize within centrosomes is …

Plk4 (Polo-like kinase 4) and its binding partner Asterless (Asl) are essential, conserved
centriole assembly factors that induce centriole amplification when overexpressed. Previous …

Polo-like kinases (PLK) are eukaryotic regulators of cell cycle progression, mitosis and
cytokinesis; PLK4 is a master regulator of centriole duplication. Here, we demonstrate that …