Thymoquinone-loaded nanostructured lipid carriers: preparation, gastroprotection, in vitro toxicity, and pharmacokinetic properties after extravascular administration

SI Abdelwahab, BY Sheikh, MME Taha… - International journal …, 2013 - Taylor & Francis
Background Nanostructured lipid carriers (NLCs), composed of solid and liquid lipids, and
surfactants are potentially good colloidal drug carriers. Thymoquinone is the main bioactive …

Pharmacokinetics and biodistribution of thymoquinone-loaded nanostructured lipid carrier after oral and intravenous administration into rats

FH Zakarial Ansar, SY Latifah… - International journal …, 2020 - Taylor & Francis
Background Thymoquinone (TQ), an active compound isolated from Nigella sativa, has
been proven to exhibit various biological properties such as antioxidant. Although oral …

Acute and subacute toxicity profiles of thymoquinone-loaded nanostructured lipid carrier in BALB/c mice

YS Ong, L Saiful Yazan, WK Ng… - International journal …, 2016 - Taylor & Francis
Background Thymoquinone (TQ), the predominant active lipophilic component in Nigella
sativa seed oil, has a variety of pharmacological properties such as anticancer activities …

Enhancement of bioavailability and pharmacodynamic effects of thymoquinone via nanostructured lipid carrier (NLC) formulation

M Elmowafy, A Samy, MA Raslan, A Salama, RA Said… - Aaps Pharmscitech, 2016 - Springer
Thymoquinone (TQ), obtained from black cumin (Nigella sativa), is a natural product with
anti-oxidant, anti-inflammatory, and hepatoprotective effects but unfortunately with poor …

Enhanced oral bioavailability and hepatoprotective activity of thymoquinone in the form of phospholipidic nano-constructs

C Rathore, N Upadhyay, R Kaundal… - Expert opinion on …, 2020 - Taylor & Francis
Background: The poor biopharmaceutical properties of thymoquinone (TQ) obstruct its
development as a hepatoprotective agent. To surmount the delivery challenges of TQ …

Thymoquinone loaded chitosan-Solid lipid nanoparticles: Formulation optimization to oral bioavailability study

I Rahat, M Rizwanullah, SJ Gilani… - Journal of Drug Delivery …, 2021 - Elsevier
High lipophilicity, low bioavailability, and hostile gastrointestinal (GI) environment is the
major concern in oral administration of thymoquinone (TQ). Herein, we developed chitosan …

Thymoquinone‐Loaded Nanostructured Lipid Carrier Exhibited Cytotoxicity towards Breast Cancer Cell Lines (MDA‐MB‐231 and MCF‐7) and Cervical Cancer Cell …

WK Ng, L Saiful Yazan, LH Yap… - BioMed research …, 2015 - Wiley Online Library
Thymoquinone (TQ) has been shown to exhibit antitumor properties. Thymoquinone‐loaded
nanostructured lipid carrier (TQ‐NLC) was developed to improve the bioavailability and …

Thymoquinone-loaded lipid nanocapsules with promising anticancer activity for colorectal cancer

M Selmi, A Salek, M Barboura, L Njim, A Trabelsi… - Nanoscale …, 2023 - pubs.rsc.org
Colorectal cancer (CRC) is the third most common worldwide. Depending on its stage,
chemotherapy is usually given after surgery when CRC has already metastasized to other …

Nanocarrier based formulation of Thymoquinone improves oral delivery: stability assessment, in vitro and in vivo studies

A Singh, I Ahmad, S Akhter, GK Jain, Z Iqbal… - Colloids and Surfaces B …, 2013 - Elsevier
This research aims to formulate and characterize solid lipid nanoparticles (SLNs) of
Thymoquinone (THQ-SLNs) for the effective treatment of liver cirrhosis. Formulations were …

Phospholipid nanoformulation of thymoquinone with enhanced bioavailability: Development, characterization and anti-inflammatory activity

C Rathore, NK Upadhyay, A Sharma, UR Lal… - Journal of Drug Delivery …, 2019 - Elsevier
Thymoquinone (TQ), a potent bioactive of Nigella sativa plant, is highly hydrophobic
molecule and thus associated with poor oral bioavailability. The present work proposes the …