Thymoquinone-loaded nanostructured lipid carriers: preparation, gastroprotection, in vitro toxicity, and pharmacokinetic properties after extravascular administration
Background Nanostructured lipid carriers (NLCs), composed of solid and liquid lipids, and
surfactants are potentially good colloidal drug carriers. Thymoquinone is the main bioactive …
surfactants are potentially good colloidal drug carriers. Thymoquinone is the main bioactive …
Pharmacokinetics and biodistribution of thymoquinone-loaded nanostructured lipid carrier after oral and intravenous administration into rats
FH Zakarial Ansar, SY Latifah… - International journal …, 2020 - Taylor & Francis
Background Thymoquinone (TQ), an active compound isolated from Nigella sativa, has
been proven to exhibit various biological properties such as antioxidant. Although oral …
been proven to exhibit various biological properties such as antioxidant. Although oral …
Acute and subacute toxicity profiles of thymoquinone-loaded nanostructured lipid carrier in BALB/c mice
YS Ong, L Saiful Yazan, WK Ng… - International journal …, 2016 - Taylor & Francis
Background Thymoquinone (TQ), the predominant active lipophilic component in Nigella
sativa seed oil, has a variety of pharmacological properties such as anticancer activities …
sativa seed oil, has a variety of pharmacological properties such as anticancer activities …
Enhancement of bioavailability and pharmacodynamic effects of thymoquinone via nanostructured lipid carrier (NLC) formulation
Thymoquinone (TQ), obtained from black cumin (Nigella sativa), is a natural product with
anti-oxidant, anti-inflammatory, and hepatoprotective effects but unfortunately with poor …
anti-oxidant, anti-inflammatory, and hepatoprotective effects but unfortunately with poor …
Enhanced oral bioavailability and hepatoprotective activity of thymoquinone in the form of phospholipidic nano-constructs
C Rathore, N Upadhyay, R Kaundal… - Expert opinion on …, 2020 - Taylor & Francis
Background: The poor biopharmaceutical properties of thymoquinone (TQ) obstruct its
development as a hepatoprotective agent. To surmount the delivery challenges of TQ …
development as a hepatoprotective agent. To surmount the delivery challenges of TQ …
Thymoquinone loaded chitosan-Solid lipid nanoparticles: Formulation optimization to oral bioavailability study
High lipophilicity, low bioavailability, and hostile gastrointestinal (GI) environment is the
major concern in oral administration of thymoquinone (TQ). Herein, we developed chitosan …
major concern in oral administration of thymoquinone (TQ). Herein, we developed chitosan …
Thymoquinone‐Loaded Nanostructured Lipid Carrier Exhibited Cytotoxicity towards Breast Cancer Cell Lines (MDA‐MB‐231 and MCF‐7) and Cervical Cancer Cell …
WK Ng, L Saiful Yazan, LH Yap… - BioMed research …, 2015 - Wiley Online Library
Thymoquinone (TQ) has been shown to exhibit antitumor properties. Thymoquinone‐loaded
nanostructured lipid carrier (TQ‐NLC) was developed to improve the bioavailability and …
nanostructured lipid carrier (TQ‐NLC) was developed to improve the bioavailability and …
Thymoquinone-loaded lipid nanocapsules with promising anticancer activity for colorectal cancer
M Selmi, A Salek, M Barboura, L Njim, A Trabelsi… - Nanoscale …, 2023 - pubs.rsc.org
Colorectal cancer (CRC) is the third most common worldwide. Depending on its stage,
chemotherapy is usually given after surgery when CRC has already metastasized to other …
chemotherapy is usually given after surgery when CRC has already metastasized to other …
Nanocarrier based formulation of Thymoquinone improves oral delivery: stability assessment, in vitro and in vivo studies
This research aims to formulate and characterize solid lipid nanoparticles (SLNs) of
Thymoquinone (THQ-SLNs) for the effective treatment of liver cirrhosis. Formulations were …
Thymoquinone (THQ-SLNs) for the effective treatment of liver cirrhosis. Formulations were …
Phospholipid nanoformulation of thymoquinone with enhanced bioavailability: Development, characterization and anti-inflammatory activity
Thymoquinone (TQ), a potent bioactive of Nigella sativa plant, is highly hydrophobic
molecule and thus associated with poor oral bioavailability. The present work proposes the …
molecule and thus associated with poor oral bioavailability. The present work proposes the …