Abstract New series of triazolo [4, 3-c] quinazolines were designed, synthesized and their
structures were elucidated using different spectroscopic techniques. They were evaluated …

Two new series of diethyl 2-[2-(substituted-2-oxo-1, 2-dihydroquinolin-4-yl) hydrazono]-
succinates 6a-g and 1-(2-oxo-1, 2-dihydroquinolin-4-yl)-1H-pyrazoles 7a-f have been …

Two new series of oxadiazole and pyrazoline derivatives were designed and synthesized as
promising EGFR-TK inhibitors. The in vitro antiproliferative activity was studied against three …

The in vitro anticancer efficacy of a new series of quinazoline-based thiazole derivatives was
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …

We report a series of hybrid quinazoline‐1, 3, 5‐triazine derivatives as EGFR inhibitors,
which were synthesised and tested by using a variety of in vitro, in silico, and in vivo …

Herein, we synthesized some new fused [1, 2, 3] triazolo-pyrrolo [1, 2-a] pyrido [4, 3-d]
pyrimidines via click chemistry followed by carbon-carbon bond coupling as key approach …

The present study describes the synthesis of 6-bromo-2-(pyridin-3-yl)-4-substituted
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …

Six series of quinazoline derivatives bearing oxazole or imidazole (8a–f, 9a–f, 10a–d, 11a–f,
12a–d and 13a–i) were designed, synthesized and their IC50 values evaluated against …

Tyrosine protein kinases (TKs) have been proved to play substantial roles on many cellular
processes and their overexpression tend to be found in various types of cancers. Therefore …

Targeting the epidermal growth factor receptors (EGFRs) with small inhibitor molecules has
been validated as a potential therapeutic strategy in cancer therapy. Pyrazolo [3, 4‐d] …