Prevention of severe toxic liver injury and oxidative stress in MCP-1-deficient mice
E Zamara, S Galastri, S Aleffi, I Petrai, M Aragno… - Journal of …, 2007 - Elsevier
BACKGROUND/AIMS: Administration of carbon tetrachloride determines liver injury,
inflammation and oxidative stress, but the molecular mechanisms of damage are only …
inflammation and oxidative stress, but the molecular mechanisms of damage are only …
Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury
C Baeck, A Wehr, KR Karlmark, F Heymann, M Vucur… - Gut, 2012 - gut.bmj.com
Objective Monocyte chemoattractant protein-1 (MCP-1, CCL2), the primary ligand for
chemokine receptor C–C chemokine receptor 2 (CCR2), is increased in livers of patients …
chemokine receptor C–C chemokine receptor 2 (CCR2), is increased in livers of patients …
Monocyte chemoattractant protein 1 (MCP‐1) expression occurs in toxic rat liver injury and human liver disease
MJ Czaja, A Geerts, J Xu… - Journal of leukocyte …, 1994 - Wiley Online Library
Considerable evidence suggests that monocytes/macrophages play a crucial role in the
process of liver injury and repair. Recent investigations have focused on the function of …
process of liver injury and repair. Recent investigations have focused on the function of …
Expression of monocyte chemotactic protein-1 precedes monocyte recruitment in a rat model of acute liver injury, and is modulated by vitamin E.
F Marra, R DeFranco, C Grappone… - … Medicine: the Official …, 1999 - europepmc.org
Background Increased expression of monocyte chemotactic protein-1 (MCP-1) has been
indicated as a mechanism underlying leukocyte recruitment after liver injury. In this study we …
indicated as a mechanism underlying leukocyte recruitment after liver injury. In this study we …
Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats
SW Luckey, DR Petersen - Experimental and molecular pathology, 2001 - Elsevier
Kupffer cells are involved in the pathogenesis of chemically mediated liver injury through
release of biologically active mediators that promote the pathogenic process. The purpose of …
release of biologically active mediators that promote the pathogenic process. The purpose of …
Anti-monocyte chemoattractant protein-1 gene therapy prevents dimethylnitrosamine-induced hepatic fibrosis in rats
S Tsuruta, M Nakamuta, M Enjoji… - International …, 2004 - spandidos-publications.com
Abstract Monocyte chemoattractant protein-1 (MCP-1) has been implicated in the process of
hepatic inflammation, recruiting monocytes and lymphocytes during liver injury. MCP-1 also …
hepatic inflammation, recruiting monocytes and lymphocytes during liver injury. MCP-1 also …
The role of Kupffer cells in carbon tetrachloride intoxication in mice
K Kiso, S Ueno, M Fukuda, I Ichi… - Biological and …, 2012 - jstage.jst.go.jp
Carbon tetrachloride (CCl4)-induced acute hepatitis is assumed to involve two phases. The
initial phase, initiated within 2 h after CCl4 administration, involves the generation of reactive …
initial phase, initiated within 2 h after CCl4 administration, involves the generation of reactive …
[HTML][HTML] Systemic MCP-1 levels derive mainly from injured liver and are associated with complications in cirrhosis
A Queck, H Bode, FE Uschner, MJ Brol, C Graf… - Frontiers in …, 2020 - frontiersin.org
Background and Aims: Monocyte chemotactic protein-1 (MCP-1) is a potent chemoattractant
for monocytes. It is involved in pathogenesis of several inflammatory diseases. Hepatic MCP …
for monocytes. It is involved in pathogenesis of several inflammatory diseases. Hepatic MCP …
Exaggerated hepatic injury due to acetaminophen challenge in mice lacking CC chemokine receptor 2
CM Hogaboam, CL Bone-Larson… - The American journal of …, 2000 - Elsevier
Monocyte chemoattractant protein-1 is one of the major CC chemokines that has been
implicated in liver injury. The CC chemokine receptor, CCR2, has been identified as the …
implicated in liver injury. The CC chemokine receptor, CCR2, has been identified as the …
[PDF][PDF] An essential role for monocyte chemoattractant protein‐1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice
P Mandrekar, A Ambade, A Lim, G Szabo… - …, 2011 - Wiley Online Library
The importance of chemokines in alcoholic liver injury has been implicated. The role of the
chemokine, monocyte chemoattractant protein‐1 (MCP‐1), elevated in patients with …
chemokine, monocyte chemoattractant protein‐1 (MCP‐1), elevated in patients with …