Simple Summary Osteosarcoma (OS), the most common primary bone tumor, mainly affects
children and adolescents. Unfortunately, in some cases, the absence of response to …

Osteosarcoma (OS) is the most common and aggressive primary malignant type of bone
cancer in children and adolescents. Chemotherapy is one of the most important treatments …

Simple Summary Osteosarcoma is the most common cancer of the bone for children and
adolescents. Although chemotherapy regimens have been widely available and effective for …

Osteosarcoma is the most common primary malignant bone tumour in children and
adolescents. Due to micrometastatic spread, radical surgery alone rarely results in cure …

For patients with osteosarcoma, the use of chemotherapy has improved survival from 11%
with surgical resection alone in the 1960s, to 70% by the mid-1980s. However, survival has …

Simple Summary Despite the adoption of aggressive, multimodal treatment schedules, the
cure rate of high-grade osteosarcoma (HGOS) has not significantly improved in the last 30 …

Due to the emergence of adjuvant and neoadjuvant chemotherapy, the survival rate has
been greatly improved in osteosarcoma (OS) patients with localized disease. However, this …

Simple Summary Osteosarcoma is the most common malignant bone tumor in children, with
a 5-year survival rate ranging from 70% to 20% depending on the aggressiveness of the …

Osteosarcoma is the most common malignant primary bone tumor in children and
adolescents. Current optimal treatment for osteosarcoma consists of multi-agent …

Purpose Multiple drug resistance due to P-glycoprotein (P-gp) expression has been
reported to be a cause of disease recurrence in osteosarcoma. Tumor specimens derived …