Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that has a broad
spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70 …

Systemic lupus erythematosus is a heterogeneous autoimmune disease marked by the
presence of pathogenic autoantibodies, immune dysregulation, and chronic inflammation …

Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease characterized
by immune complex formation with multi-organ manifestations. Lupus nephritis (LN) is one …

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by a
loss of tolerance to self-antigens and the production of high titers of serum autoantibodies …

Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by the
formation of a variety of autoantibodies and subsequent development of severe …

SLE is a chronic inflammatory disease that affects the kidneys in about 50% of patients.
Lupus nephritis is a major risk factor for overall morbidity and mortality in SLE, and despite …

Sle1 and Sle3 are 2 loci that confer susceptibility to lupus nephritis in the NZM2410 strain of
mice. Our previous work has shown that B6. NZMc1 mice, congenic for Sle1, exhibit loss of …

Genetic factors exert an important role in determining Systemic Lupus Erythematosus (SLE)
susceptibility, interplaying with environmental factors. Several genetic studies in various SLE …

Genetic variation was first shown to be important in systemic lupus erythematosus (SLE or
lupus) in the 1970s with associations in the human leukocyte antigen region. Almost four …

We are currently witnessing an explosion of information about the genetic contribution to
complex human diseases such as systemic lupus erythematosus (SLE). These genetic …