Gene fusions are one of the most common genomic alterations in pediatric cancer. Many
fusions encode oncogenic drivers and play important roles in cancer diagnosis, risk …

PURPOSE Gene fusions play a significant role in cancer etiology, making their detection
crucial for accurate diagnosis, prognosis, and determining therapeutic targets. Current …

Background Gene fusions are important cancer drivers in pediatric cancer and their accurate
detection is essential for diagnosis and treatment. Clinical decision-making requires high …

The incidence of pediatric cancers is rising steadily across the world, along with the
challenges in understanding the molecular mechanisms and devising effective therapeutic …

We hypothetized that pediatric cancers would more likely harbor fusion transcripts. To
dissect the complexity of the fusions landscape in recurrent solid pediatric cancers, we …

Background Pediatric cancers typically have a distinct genomic landscape when compared
to adult cancers and frequently carry somatic gene fusion events that alter gene expression …

Pediatric cancers differ from adult tumors, especially by their very low mutational rate.
Therefore, their etiology could be explained in part by other oncogenic mechanisms such as …

Background Methods for identifying gene fusion events, such as fluorescence in situ
hybridization (FISH), immunohistochemistry (IHC), and transcriptome analysis, are either …

Fusion genes are hybrid genes that combine parts of two or more original genes. They can
form as a result of chromosomal rearrangements or abnormal transcription, and have been …

Fusion genes have pivotal roles in the development and progression of human cancer and
offer potential for rational drug design. Massively parallel sequencing has identified a …