Botulinum neurotoxins beyond neurons: Interplay with glial cells
S Luvisetto - Toxins, 2022 - mdpi.com
In recent years, numerous studies have highlighted the significant use of botulinum
neurotoxins (BoNTs) in the human therapy of various motor and autonomic disorders. The …
neurotoxins (BoNTs) in the human therapy of various motor and autonomic disorders. The …
Botulinum neurotoxins in central nervous system: An overview from animal models to human therapy
S Luvisetto - Toxins, 2021 - mdpi.com
Botulinum neurotoxins (BoNTs) are potent inhibitors of synaptic vesicle fusion and
transmitter release. The natural target of BoNTs is the peripheral neuromuscular junction …
transmitter release. The natural target of BoNTs is the peripheral neuromuscular junction …
Central effects of botulinum neurotoxin—evidence from human studies
D Weise, CM Weise, M Naumann - Toxins, 2019 - mdpi.com
For more than three decades, Botulinum neurotoxin (BoNT) has been used to treat a variety
of clinical conditions such as spastic or dystonic disorders by inducing a temporary paralysis …
of clinical conditions such as spastic or dystonic disorders by inducing a temporary paralysis …
Neuronal selectivity of botulinum neurotoxins
B Poulain, E Lemichez, MR Popoff - Toxicon, 2020 - Elsevier
Botulinum neurotoxins (BoNTs) are highly potent toxins responsible for a severe disease,
called botulism. They are also efficient therapeutic tools with an increasing number of …
called botulism. They are also efficient therapeutic tools with an increasing number of …
Botulinum neurotoxins: biology, pharmacology, and toxicology
M Pirazzini, O Rossetto, R Eleopra… - Pharmacological …, 2017 - ASPET
The study of botulinum neurotoxins (BoNT) is rapidly progressing in many aspects. Novel
BoNTs are being discovered owing to next generation sequencing, but their biologic and …
BoNTs are being discovered owing to next generation sequencing, but their biologic and …
Exploiting botulinum neurotoxins for the study of brain physiology and pathology
Botulinum neurotoxins are metalloproteases that specifically cleave N-ethylmaleimide-
sensitive factor attachment protein receptor (SNARE) proteins in synaptic terminals, resulting …
sensitive factor attachment protein receptor (SNARE) proteins in synaptic terminals, resulting …
Botulinum neurotoxins: mechanism of action
O Rossetto, M Pirazzini, F Fabris… - Botulinum Toxin …, 2021 - Springer
Botulinum neurotoxins (BoNTs) are a growing family of bacterial protein toxins that cause
botulism, a rare but often fatal animal and human disease. They are the most potent toxins …
botulism, a rare but often fatal animal and human disease. They are the most potent toxins …
Manipulation of signal transduction by botulinum neurotoxins and their derivatives
JA Chaddock, KA Foster - Current Signal Transduction …, 2007 - ingentaconnect.com
Botulinum neurotoxins produced by various Clostridium sp are the most potent acute lethal
toxins known, and yet they have found increasing use in the clinical treatment of diseases or …
toxins known, and yet they have found increasing use in the clinical treatment of diseases or …
Intracerebrally applied botulinum neurotoxin in experimental neuroscience
A Hawlitschka, V Antipova, O Schmitt… - Current …, 2013 - ingentaconnect.com
The use of botulinum neurotoxins (BoNTs) for therapeutic purposes in neuromuscular
disorders and peripheral hypercholinergic conditions as well as in aesthetic medicine is …
disorders and peripheral hypercholinergic conditions as well as in aesthetic medicine is …
Clinical uses of botulinum neurotoxins: current indications, limitations and future developments
S Chen - Toxins, 2012 - mdpi.com
Botulinum neurotoxins (BoNTs) cause flaccid paralysis by interfering with vesicle fusion and
neurotransmitter release in the neuronal cells. BoNTs are the most widely used therapeutic …
neurotransmitter release in the neuronal cells. BoNTs are the most widely used therapeutic …
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