Background Administering β-lactam antibiotics via prolonged infusions for critically ill
patients is mainly based on preclinical evidence. Preclinical data on this topic have not been …

Beta-lactam antibiotics display time-dependant pharmacodynamics whereby constant
antibiotic concentrations rather than high peak concentrations are most likely to result in …

Continuous infusion of β-lactam antibiotics has been widely promoted to optimise their time-
dependent activity. Increasing evidence is emerging suggesting potential benefits in patient …

Introduction: Beta-lactams are at the cornerstone of therapy in critical care settings, but their
clinical efficacy is challenged by the rise in bacterial resistance. Infections with multi-drug …

Prolonged infusion (PI) of β-lactam antibiotics is increasingly used in order to optimise
antibiotic exposure in critically ill patients. Physicians are often not aware of a number of …

Given the sparse antibiotic pipeline and the increasing prevalence of resistant organisms,
efforts should be made to optimise the pharmacodynamic exposure of currently available …

Objective This overview of reviews aims to map and compare of objectives, methods, and
findings of existing systematic reviews to develop a greater understanding of the information …

Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …

There is controversy over whether traditional intermittent bolus dosing or continuous infusion
of beta-lactam antibiotics is preferable in critically ill patients. No significant difference …

Pre-clinical pharmacokinetic–pharmacodynamic assessments indicate Beta-lactam
antibiotics have time-dependent killing, variable persistent antibiotic effects and that free …