The importance of patient-reported outcomes such as health-related quality of life (HRQL) in
clinical research is increasingly acknowledged. In order to yield valid results, the …

Background: A large proportion of patients worldwide under treatment for hypothyroidism
with thyroxine show suboptimal Thyroid Stimulating Hormone (TSH) values. There is a …

Background: Until recently, treatment of hypothyroidism has been accomplished using
monotherapy of synthetic L-thyroxine (L-T4) sodium tablets that should be taken 30-60 …

Objective Many patients treated for primary hypothyroidism have an unexplained reduced
quality of life (QOL). We studied the relation between QOL and various parameters in treated …

Hypothyroidism affects up to 5% of the general population, with a further estimated 5% being
undiagnosed. Over 99% of affected patients suffer from primary hypothyroidism. Worldwide …

Background: A significant number of patients show sub-optimal adherence to levothyroxine
(LT4) therapy, mainly because they have to postpone their breakfast by at least 30 min. The …

Patient-reported outcomes (PROs) are increasingly used in clinical practice to improve
clinical care. Multiple studies show that systematic use of PROs can enhance …

Objectives Hypothyroid patients managed with excessive or insufficient thyroid replacement
therapy are often difficult to clinically recognize. Monitoring may prevent or minimize the …

Abstract Context Between 10% and 15% of people with hypothyroidism experience
persistent symptoms, despite achieving biochemical euthyroidism. The underlying causes …

Background. Mild or subclinical hypothyroidism [raised thyroid-stimulating hormone (TSH)
but normal free thyroxine (T4)] affects 5–10% of adults. Symptoms are non-specific and TSH …