Novel drug development for amyotrophic lateral sclerosis

O Hurko, FS Walsh - Journal of the neurological sciences, 2000 - Elsevier
Amyotrophic lateral sclerosis (ALS) has become an increasingly attractive area for the
pharmaceutical industry, the most experimentally tractable of the neurodegenerative …

Riluzole for ALS: what is the evidence?

R Miller - Amyotrophic Lateral Sclerosis and Other Motor Neuron …, 2003 - Taylor & Francis
It has been eight years since the Food and Drug Administration approved riluzole as the
only drug of established value in slowing disease progression for patients with ALS. The …

Potential therapeutic drugs and methods for the treatment of amyotrophic lateral sclerosis

G Yacila, Y Sari - Current medicinal chemistry, 2014 - ingentaconnect.com
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder caused by damage of
motoneurons leading to paralysis state and long term disability. Riluzole is currently the only …

Therapeutic developments in amyotrophic lateral sclerosis

EC Lai - Expert Opinion on Investigational Drugs, 1999 - Taylor & Francis
There is currently no effective treatment for amyotrophic lateral sclerosis (ALS), a
devastating disorder of the human nervous system that, due to motoneurone degeneration …

Emerging targets and treatments in amyotrophic lateral sclerosis

L Zinman, M Cudkowicz - The Lancet Neurology, 2011 - thelancet.com
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease that is currently
untreatable. Many compounds have been tested in laboratory-based models and in patients …

[HTML][HTML] Advances in understanding and treating amyotrophic lateral sclerosis (ALS): A comprehensive review

D Gupta, S Vagha, H Dhingra, H Shirsath - Cureus, 2023 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS) is a deadly CNS neurodegenerative disease. The way
ALS is now managed, from diagnosis to prognosis, is still not ideal despite many studies …

New developments and opportunities in drugs being trialed for amyotrophic lateral sclerosis from 2020 to 2022

JS Jiang, Y Wang, M Deng - Frontiers in pharmacology, 2022 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that
primarily affects motor neurons in the brain and spinal cord. In the recent past, there have …

Amyotrophic lateral sclerosis disease modifying therapeutics: a cell biological perspective

BL Tang - Neural regeneration research, 2017 - journals.lww.com
Amyotrophic lateral sclerosis (ALS) is a progressively fatal neuromuscular disorder
classically characterized by loss of upper and lower motor neurons from the cortex to the …

New therapy options for amyotrophic lateral sclerosis

P Gordon, P Corcia, V Meininger - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative
disease leading almost irrevocably to paralysis and death within 5 years after the first …

Riluzole, neuroprotection and amyotrophic lateral sclerosis

BC Cheah, S Vucic, AV Krishnan… - Current medicinal …, 2010 - ingentaconnect.com
Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease of the
human motor system. Aetiological mechanisms implicated in the development of ALS have …