The development of the disease modifying drug, riluzole, is changing the natural history of
amyotrophic lateral sclerosis (ALS). Let us take the 'classic'ALS patient as portrayed by ALS …

Fifteen years ago, a role for excitotoxic damage in the pathology of amyotrophic lateral
sclerosis (ALS) was postulated. This stimulated the development of riluzole, the only …

Background Amyotrophic lateral sclerosis is a progressive motor neuron disease for which
there is no adequate treatment. Some research suggests that the excitatory amino acid …

Riluzole Page 1 Supplement Riluzole Deborah F Gelinas ALS and other motor neuron disorders
2000 (Suppl 4), 3–4 © 2000 ALS and other motor neuron disorders. All rights reserved. ISSN …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disease of
adults which preferentially attacks the neuromotor system. Riluzole has been used as the …

BACKGROUND: Riluzole 100 mg probably prolongs survival in patients with amyotrophic
lateral sclerosis by about two months and the safety of the drug is not a major concern. The …

The ALS clinical trial landscape is currently highly active with several promising innovative
developments and therapeutic options. By further refinement of evidence-based guidelines …

Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive, fatal, neurodegenerative
disease. Although the pathogenesis remains unresolved, oxidative stress is known to play a …

Introduction: Amyotrophic lateral sclerosis (ALS) is one of the most devastating neurological
disorders, affecting approximately half a million people worldwide. Currently there is no cure …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease for which
no cure or effective treatment presently exists. Many different types of drugs have been …