Histories of depression, allopregnanolone responses to stress, and premenstrual symptoms in women

RR Klatzkin, AL Morrow, KC Light, CA Pedersen… - Biological …, 2006 - Elsevier
Twenty-six women meeting DSM criteria for premenstrual dysphoric disorder (PMDD) and
39 non-PMDD controls were tested for allopregnanolone (ALLO) responses to mental stress …

Allopregnanolone levels and reactivity to mental stress in premenstrual dysphoric disorder

SS Girdler, PA Straneva, KC Light, CA Pedersen… - Biological …, 2001 - Elsevier
Background: This study was designed to examine basal and stress-induced levels of the
neuroactive progesterone metabolite, allopregnanolone, in women with premenstrual …

Associations of histories of depression and PMDD diagnosis with allopregnanolone concentrations following the oral administration of micronized progesterone

RR Klatzkin, AL Morrow, KC Light, CA Pedersen… - …, 2006 - Elsevier
Twenty-three women with premenstrual dysphoric disorder (PMDD) and 29 non-PMDD
controls were compared for plasma progesterone (P) and its neuroactive steroid metabolite …

Allopregnanolone serum concentrations and diurnal cortisol secretion in women with premenstrual dysphoric disorder

B Segebladh, E Bannbers, L Moby, S Nyberg… - Archives of women's …, 2013 - Springer
Most prior studies in patients with premenstrual dysphoric disorder (PMDD) indicate a
blunted hypothalamus–pituitary–adrenal axis function. However, the relationship between …

Allopregnanolone levels and symptom improvement in severe premenstrual syndrome

EW Freeman, CA Frye, K Rickels… - Journal of clinical …, 2002 - journals.lww.com
Allopregnanolone is a neuroactive metabolite of progesterone and a barbiturate-like
modulator of central γ-aminobutyric acid A receptors that modify a range of behaviors …

Neurosteroids in the context of stress: implications for depressive disorders

SS Girdler, R Klatzkin - Pharmacology & therapeutics, 2007 - Elsevier
Animal models indicate that the neuroactive steroids 3α, 5α-THP (allopregnanolone) and 3α,
5α-THDOC (allotetrahydroDOC) are stress responsive, serving as homeostatic mechanisms …

Allopregnanolone as a mediator of affective switching in reproductive mood disorders

CE Schiller, PJ Schmidt, DR Rubinow - Psychopharmacology, 2014 - Springer
Rationale Reproductive mood disorders, including premenstrual dysphoria (PMD) and
postpartum depression (PPD), are characterized by affective dysregulation that occurs …

Ethnic differences in allopregnanolone concentrations in women during rest and following mental stress

SS Girdler, M Beth Mechlin, KC Light… - …, 2006 - Wiley Online Library
The neuroactive steroid allopregnanolone (ALLO) is stress sensitive, negatively modulates
the HPA axis, and has been implicated in mood disorders. We examined ethnic differences …

Relationship between allopregnanolone and negative mood in postmenopausal women taking sequential hormone replacement therapy with vaginal progesterone

L Andréen, I Sundström-Poromaa, M Bixo… - …, 2005 - Elsevier
Objective: To compare severity of negative mood and physical symptoms between women
with different progesterone, allopregnanolone, and pregnanolone plasma concentrations …

Disadaptive disorders in women: allopregnanolone, a sensitive steroid

F Bernardi, N Pluchino, S Begliuomini… - Gynecological …, 2004 - Taylor & Francis
Allopregnanolone, a neurosteroid acting as a potent anxiolytic agonist of the γ-aminobutyric
acid A receptor, has been shown in animal models to modify its concentrations at central …