Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

The brain comprises many different cell types with specialized functions which respond and
adapt to the continuously changing environment, through tight spatiotemporal regulation of …

The complexity of the human brain emerges from a long and finely tuned developmental
process orchestrated by the crosstalk between genome and environment. Vis à vis other …

Postmitotic neurons are subject to a vast array of environmental influences that require the
nuclear integration of intracellular signaling events to promote a wide variety of neuroplastic …

The generation of individual neurons (neurogenesis) during cortical development occurs in
discrete steps that are subtly regulated and orchestrated to ensure normal histogenesis and …

Neural stem cells generate distinct cell types for tissue formation and cell replacement
during development and throughout adulthood. Neural development and plasticity are …

Highlights•Chd chromatin remodeling enzymes govern distinct phases of neuronal
connectivity.•Chd4 orchestrates afferent and efferent neuronal connectivity via distinct …

Neurons are dynamic cells that respond and adapt to stimuli throughout their long
postmitotic lives. The structural and functional plasticity of neurons requires the regulated …

Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

A key question in developmental biology is how cellular differentiation is controlled during
development. While transitions between trithorax-group (TrxG) and polycomb-group (PcG) …