Considerable evidence suggests loss-of-function mutations in the chromatin remodeler
CHD2 contribute to a broad spectrum of human neurodevelopmental disorders. However, it …

Long-term memory formation requires the coordinated regulation of gene expression. Until
recently nucleosome remodeling, one of the major epigenetic mechanisms for controlling …

Chromatin is organized into multiscale three-dimensional structures, including chromosome
territories, A/B compartments, topologically associating domains, and chromatin loops. This …

The development and function of neurons require the regulated expression of large
numbers of very specific gene sets. Epigenetic modifications of both DNA and histone …

The timely transition from neural progenitor to post-mitotic neuron requires down-regulation
and loss of the neuronal transcriptional repressor, REST. Here, we have used mice …

Neural development requires the orchestration of dynamic changes in gene expression to
regulate cell fate decisions. This regulation is heavily influenced by epigenetics, heritable …

The regulation of chromatin by epigenetic mechanisms plays a central role in gene
expression and is essential for development and maintenance of cell identity and function …

BACKGROUND: The development of the nervous system is a highly organized process
involving the precise and coordinated timing of many complex events. These events require …

Background DNA-protein interactions in mature brain are increasingly recognized as key
regulators for behavioral plasticity and neuronal dysfunction in chronic neuropsychiatric …

Alterations in the epigenetic modulation of gene expression have been implicated in several
developmental disorders, cancer, and recently, in a variety of mental retardation and …