During mammalian development, differences in chromatin state coincide with cellular
differentiation and reflect changes in the gene regulatory landscape. In the developing brain …

The proneural transcription factor Ascl1 coordinates gene expression in both proliferating
and differentiating progenitors along the neuronal lineage. Here, we used a cellular model …

Differences in chromatin organization are key to the multiplicity of cell states that arise from a
single genetic background, yet the landscapes of in vivo tissues remain largely uncharted …

Brain development is a life-long process that encompasses several critical periods of
transition, during which significant cognitive changes occur. Embryonic development …

DNA sequencing-based studies of neurodevelopmental disorders (NDDs) have identified a
wide range of genetic determinants. However, a comprehensive analysis of these data, in …

To identify chromatin mechanisms of neuronal differentiation, we characterized chromatin
accessibility and gene expression in cerebellar granule neurons (CGNs) of the developing …

Chromatin remodelers are key players in the regulation of chromatin accessibility and
nucleosome positioning on the eukaryotic DNA, thereby essential for all DNA dependent …

Chromatin remodeling complexes play critical roles in development. Here we describe a
transcription factor, CECR2, which is involved in neurulation and chromatin remodeling …

Glioblastoma, the most common and aggressive malignant brain tumor, is propagated by
stem-like cancer cells refractory to existing therapies. Understanding the molecular …

Chromatin structure is intimately connected with gene expression and cell identity. Here we
review recent advances in the field and discuss how establishment of cell identity during …