Immunity, atherosclerosis and cardiovascular disease

J Frostegård - BMC medicine, 2013 - Springer
Atherosclerosis, the major cause of cardiovascular disease (CVD), is a chronic inflammatory
condition with immune competent cells in lesions producing mainly pro-inflammatory …

Treating inflammation in atherosclerotic cardiovascular disease: emerging therapies

R Klingenberg, GK Hansson - European heart journal, 2009 - academic.oup.com
Atherosclerosis constitutes the underlying disease to the clinical manifestations of
myocardial infarction, stroke, and gangrene. Despite the success of statins, prevention of …

[HTML][HTML] Chronic inflammatory diseases and endothelial dysfunction

X Castellon, V Bogdanova - Aging and disease, 2016 - ncbi.nlm.nih.gov
Chronic inflammatory diseases are associated with increases in cardiovascular diseases
(CVD) and subclinical atherosclerosis as well as early-stage endothelial dysfunction …

Inflammation and atherosclerosis: direct versus indirect mechanisms

ME Rosenfeld - Current opinion in pharmacology, 2013 - Elsevier
It is now widely accepted that the development of atherosclerotic lesions involves a chronic
inflammatory response that includes both innate and adaptive immune mechanisms …

Role of vascular inflammation in coronary artery disease: potential of anti-inflammatory drugs in the Prevention of atherothrombosis: inflammation and anti …

DM Moreira, RL da Silva, JL Vieira, T Fattah… - American Journal of …, 2015 - Springer
Coronary artery disease (CAD) and acute myocardial infarction (AMI) are inflammatory
pathologies, involving interleukins (ILs), such as IL-1β, IL-6 and tumor necrosis factor (TNF) …

[HTML][HTML] Inflammation and cardiovascular disease: the future

N Arnold, K Lechner, C Waldeyer… - European Cardiology …, 2021 - ncbi.nlm.nih.gov
Despite considerable advances in reducing the global burden of atherosclerotic
cardiovascular disease by targeting conventional risk factors, significant residual risk …

[HTML][HTML] Inflammation and cardiovascular disease: From mechanisms to therapeutics

A Alfaddagh, SS Martin, TM Leucker, ED Michos… - American journal of …, 2020 - Elsevier
Inflammation constitutes a complex, highly conserved cascade of molecular and cellular
events. Inflammation has been labeled as “the fire within,” is highly regulated, and is critical …

Inflammation in atherosclerosis and implications for therapy

R Paoletti, AM Gotto Jr, DP Hajjar - Circulation, 2004 - Am Heart Assoc
Atherosclerosis is now understood to be a disease characterized by inflammation that
results in a host of complications, including ischemia, acute coronary syndromes (unstable …

A link between inflammation and thrombosis in atherosclerotic cardiovascular diseases: Clinical and therapeutic implications

E Oikonomou, M Leopoulou, P Theofilis… - Atherosclerosis, 2020 - Elsevier
The association between thrombosis and acute coronary syndromes is well established.
Inflammation and activation of innate and adaptive immunity are another important factor …

Inflammation and cardiovascular diseases: the most recent findings

D Sorriento, G Iaccarino - International journal of molecular sciences, 2019 - mdpi.com
The series of reactive biological events that we identify as inflammation has been
investigated in recent years and unveiled as an important mechanism for regeneration. The …