Tumor necrosis factor (TNF) was originally described as a protein factor capable of killing
tumor cells in vitro and causing hemorrhagic necrosis of transplantable tumors in mice. 1, 2 …

The production of several pro-inflammatory cytokines is increased in inflammatory bowel
diseases (IBD). Experimental models of IBD have further defined the importance of specific …

Tumor necrosis factor (TNF)-α is a potent proinflam-matory cytokine that orchestrates
inflammatory responses by activating a wide range of cells. These effects are mediated by …

Ulcerative colitis (UC) and Crohn's disease (CD) are part of Inflammatory Bowel Diseases
(IBD) and have pathophysiological processes such as bowel necrosis and enteric neurons …

Anti-tumor necrosis factor (TNF) antibodies are successfully used in the therapy of
inflammatory bowel diseases (IBD). However, the molecular mechanism of action of these …

Crohn's disease and ulcerative colitis are two idiopathic inflammatory disorders of the GI
tract. Manifestations of disease can be severe and lead to long term therapy with a variety of …

Tumor Necrosis Factor Inhibitors for Inflammatory Bowel Disease | NEJM Skip to main content
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Biological treatment with tumor necrosis factor (TNF) inhibitors is successful in the
management of inflammatory bowel disease (IBD). All TNF inhibitors antagonize the pro …

Although activity that induced tumor regression was observed and termed tumor necrosis
factor (TNF) as early as the 1960s, the true identity of TNF was not clear until 1984, when …

Tumor necrosis factor (TNF) and lymphotoxin-α were isolated more than 10 years ago, on
the basis of their ability to kill tumor cells in vitro and to cause hemorrhagic necrosis of …