IgG from atopic dermatitis patients induces non‐atopic infant thymic invariant natural killer T (iNKT) cells to produce IL‐4, IL‐17, and IL‐10

LS Santos, FR Sgnotto, TR Sousa… - International journal …, 2020 - Wiley Online Library
Background Atopic dermatitis (AD) pathogenesis still needs to be elucidated, but invariant
natural killer T (iNKT) cell involvement was already described by several groups. Our group …

IgG from atopic dermatitis patients induces IL‐17 and IL‐10 production in infant intrathymic TCD 4 and TCD 8 cells

FDR Sgnotto, MG de Oliveira, AAL Lira… - International journal …, 2018 - Wiley Online Library
Introduction Our group recently demonstrated that IgG modulates αβT cell cytokine
production during the maturation process in the human thymus. The effects of this …

Altered peripheral invariant natural killer T cells in atopic dermatitis

E Gyimesi, G Nagy, É Remenyik, S Sipka… - Journal of clinical …, 2011 - Springer
Background Conflicting data exist on the number of invariant NKT (iNKT) cells in atopic
dermatitis (AD); furthermore, no data have been published on their functional capacity …

Thymic stromal lymphopoietin–activated invariant natural killer T cells trigger an innate allergic immune response in atopic dermatitis

WH Wu, CO Park, SH Oh, HJ Kim, YS Kwon… - Journal of Allergy and …, 2010 - Elsevier
BACKGROUND: Although invariant natural killer T (iNKT) cells have been shown to play a
critical role in the pathogenesis of asthma, the role of iNKT cells in atopic dermatitis (AD) has …

IgG from atopic individuals can mediate non-atopic infant thymic and adult peripheral CD8+ TC2 skewing without influence on TC17 or TC22 cells.

T Rodrigues de Sousa… - European Annals of …, 2020 - europepmc.org
The potential of IgG antibodies as allergy regulators has been discussed for decades and
was brought to light that anti-allergen IgG is related to allergy inhibition in children during the …

Natural killer T cells expressing IFN‐γ and IL‐4 in lesional skin of atopic eczema

D Simon, E Kozlowski, HU Simon - Allergy, 2009 - Wiley Online Library
Background: The inflammation of atopic eczema (AE) is orchestrated not only by T cells
predominantly but also B cells, eosinophils and dendritic cells. Recently, a role of invariant …

IgG from Adult Atopic Dermatitis (AD) Patients Induces Nonatopic Neonatal Thymic Gamma–Delta T Cells (γδT) to Acquire IL-22/IL-17 Secretion Profile with Skin …

BO Fagundes, TR de Sousa, A Nascimento… - International Journal of …, 2022 - mdpi.com
γδT cells mature in the human thymus, and mainly produce IL-17A or IFN-γ, but can also
produce IL-22 and modulate a variety of immune responses. Here, we aimed to evaluate …

IgG from adult atopic dermatitis (AD) patients induces thymic IL-22 production and CLA expression on CD4+ T cells: Possible epigenetic implications mediated by …

TR de Sousa, BO Fagundes, A Nascimento… - International Journal of …, 2022 - mdpi.com
Atopic dermatitis (AD) is a common relapsing inflammatory skin disorder characterized by
immune-mediated inflammation and epidermal barrier dysfunction. The pathogenesis of AD …

CD1d restricted natural killer T cells are not required for allergic skin inflammation

A Elkhal, M Pichavant, R He, J Scott, E Meyer… - Journal of allergy and …, 2006 - Elsevier
BACKGROUND: Invariant T-cell receptor–positive natural killer (iNKT) cells have been
shown to be essential for the development of allergen-induced airway hyperreactivity (AHR) …

NK cells as a possible new player in atopic dermatitis

K Kabashima, S Weidinger - Journal of Allergy and Clinical …, 2020 - jacionline.org
Atopic dermatitis (AD) is one of the most common inflammatory skin diseases worldwide,
and is characterized by heightened type 2 signaling, in particular through IL-4 and IL-13. 1, 2 …