Although the role of CD28-B7 interaction in the activation of naive T cells is well established,
its importance in the generation and maintenance of T cell memory is not well understood. In …

Memory CD8+ T cell responses have been considered to be independent of CD80/CD86-
CD28 costimulation. However, recall responses are often severely blunted in CD28−/− mice …

The CD28/B7 costimulatory pathway is generally considered dispensable for memory T cell
responses, largely based on in vitro studies demonstrating memory T cell activation in the …

The control of many persistent viral infections by Ag-specific cytolytic CD8+ T cells requires a
concurrent virus-specific CD4+ Th cell response. This reflects in part a requirement of …

Abstract A previously unreported CD8+ CD28+ CD11b+ T cell subset occurs in healthy
individuals and expands in patients suffering from primary viral infections. In functional …

Fully functional CD8+ T cell memory is highly dependent upon CD4+ T cell support. CD4+ T
cells play a critical role in inducing the expression of CD70, the ligand for CD27, on dendritic …

CD28 is required for the development of regulatory T cells (Tregs; CD4+ CD25+ Foxp3+) in
the thymus and also contributes to their survival and homeostasis in the periphery. We …

The role of costimulation has previously been confined to the very early stages of the CD8+
T cell response. In this study, we demonstrate the requirement for CD27 costimulation during …

Whereas the role of CD4 T cells in B cell memory generation is well established and
unequivocal, the role that CD4 T cells play in CD8 responses was until recently far more …

CD30 is well recognized as a marker expressed by a heterogeneous group of lymphomas
and in several immune and autoimmune disorders. However, the function of CD30 in theses …