Conventional antimicrobials are increasingly ineffective due to the emergence of multidrug-
resistance among pathogenic microorganisms. The need to overcome these deficiencies …

Traditional antimicrobials are increasingly suffering from the emergence of multidrug
resistance among pathogenic microorganisms. To overcome these deficiencies, a range of …

The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level.
The treatment options against infections caused by multiple drug-resistant bacteria are …

Introduction: Bacteria evolved an arsenal of mechanisms to deal with toxic compounds and
metabolic stresses, including antimicrobial agents. Efflux pumps are major players in the …

The world of antibiotic drug discovery and development is driven by the necessity to
overcome antibiotic resistance in common Gram-positive and Gram-negative pathogens …

Antimicrobial resistance represents a significant challenge to future healthcare provision. An
acronym ESKAPEE has been derived from the names of the organisms recognised as the …

With the advent of antibiotics, bacterial infections were supposed to be a thing of past.
However, this instead led to the selection and evolution of bacteria with mechanisms to …

Antibiotics are vital to modern medicine. However, bacterial resistance constitutes a growing
threat to effective antimicrobial therapy worldwide. Indeed, antimicrobial resistance …

Antimicrobial resistance (AMR) has become a major problem in public health leading to an
estimated 4.95 million deaths in 2019. The selective pressure caused by the massive and …

Resistance to multiple drugs in medically important bacteria results in therapeutic
challenges for the clinician. The mechanisms by which bacteria evade the effects of …