Lung cancer is the leading cause of cancer death in men and women. Lung
adenocarcinoma (LUAD), represents approximately 40% of all lung cancer cases. Advances …

The complement cascade is a part of the innate immune system that acts primarily to remove
pathogens and injured cells. However, complement activation is also peculiarly associated …

Chronic inflammation has been linked to the initiation of carcinogenesis, as well as the
advancement of established tumors. The polarization of the tumor inflammatory …

Colorectal cancer (CRC) is the third most common malignant tumor and the second most
fatal cancer worldwide. Several parts of the immune system contribute to fighting cancer …

The tumour microenvironment (TME) highly influences the growth and spread of tumours,
thus impacting the patient's clinical outcome. In this context, the complement system plays a …

The role of complement in cancer has received increasing attention over the last decade.
Recent studies provide compelling evidence that complement accelerates cancer …

Complement is a central part of the immune system that has developed as a first defense
against non-self cells. Neoplastic transformation is accompanied by an increased capacity of …

Complement was initially discovered as an assembly of plasma proteins “complementing”
the cytolytic activity of antibodies. However, our current knowledge places this complex …

In tumour immunology, complement has traditionally been considered as an adjunctive
component that enhances the cytolytic effects of antibody-based immunotherapies, such as …

The complement system has traditionally been considered a component of innate immunity
against invading pathogens and “nonself” cells. Recent studies have demonstrated the …