Please cite this paper as: Bergen N, Jaddoe V, Timmermans S, Hofman A, Lindemans J,
Russcher H, Raat H, Steegers‐Theunissen R, Steegers E. Homocysteine and folate …

The purpose of this study is to evaluate the relationship between maternal and/or cord blood
folate/homocysteine concentrations and adverse pregnancy outcomes. The study population …

Good clinical practice recommends folic acid supplementation 1 month prior to pregnancy
and during the first trimester to prevent congenital malformations. However, high rates of …

Background: Increased total homocysteine (tHcy) may be associated with placental-
mediated adverse pregnancy outcomes, but few prospective studies have measured tHcy …

Homocysteine is an amino acid that is involved in several key metabolic processes,
including the methylation and sulphuration pathways. Blood concentrations of homocysteine …

Background: Increased homocysteine has been associated with pregnancy complications.
Methods: We investigated prospectively the effect of maternal homocysteine on normal …

Background: In many countries, current recommendations are that women take a daily 400-
μg folic acid supplement from before conception until the end of the 12th week of gestation …

Background: Total homocysteine (tHcy) measured in serum or plasma is a marker of folate
status and a risk factor for cardiovascular disease. Objective: Our objective was to …

OBJECTIVE: The purpose of this study was to determine the nutritional and genetic factors
that influence fetal plasma homocysteine concentrations. STUDY DESIGN: Maternal and …

The role of folic acid and homocysteine in pregnancy is becoming clearer. The efforts of
many countries to prevent neural tube defects through public awareness of folic acid have …