Most general population risk for schizophrenia is accounted for by common variations in the
genome, but each variant explains only a tiny fraction of increased risk. In contrast …

Technological progress is reshaping the nature versus nurture debate of disease causation.
Fifty years ago, psychiatrists used to argue over whether schizophrenia was caused by a …

Many decades of study into the genetic epidemiology of schizophrenia consistently show
familial clustering of the disorder, mostly due to genetic contributions. Early clues as to the …

The past decade has witnessed major advances in our understanding of the genetics of
schizophrenia. Large, consortia-led genomic studies involving thousands of patients and …

Over the past few years, strong evidence has accumulated that risk for schizophrenia is
influenced by a very large number of common genetic variants that individually increase risk …

In recent years, our understanding of the genetic architecture of schizophrenia, a phrase
which denotes the numbers of risk variants, their frequencies and effect sizes, has been …

Studying the phenotypic manifestations of increased genetic liability for schizophrenia can
increase our understanding of this disorder. Specifically, information from alleles identified in …

A long-established hypothesis is that schizophrenia has a strong genetic component. In the
early 1990s, the first genetic variant that substantially increases risk for psychosis was …

Background The polygenic risk score (PRS) is derived from single nucleotide
polymorphisms (SNPs) including those that are genome-wide significant and also including …

These are interesting times for schizophrenia genetics. The last 5 years has seen
unprecedented progress, moving us from debate about putative genetic models to an …