Abstract Sirtuin 6 (SIRT6) is a member of the sirtuin family NAD+-dependent deacetylases
with multiple roles in controlling organism homeostasis, lifespan, and diseases. Due to its …

SIRT6 belongs to the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases
and has established diverse roles in aging, metabolism and disease. Its function is similar to …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …

SIRT6, a member of the Sirtuin family of NAD+-dependent enzymes, has established roles in
chromatin signaling and genome maintenance. Through these functions, SIRT6 protects …

Aging is characterized by progressive functional deterioration with increased risk of
mortality. It is a complex biological process driven by a multitude of intertwined mechanisms …

SIRT6 is one of the seven members of the NAD-dependent family of sirtuins mammals. The
pleotropic identity of SIRT6 is manifested into several catalytic activities such as …

Aging is the result of the accumulation of a wide variety of molecular and cellular damage
over time. This has been associated with a number of features termed hallmarks of aging …

Aging is a chronic yet natural physiological decline of the body. Throughout life, humans are
continuously exposed to a variety of exogenous and endogenous stresses, which engender …

Mammalian sirtuins, Sirt1–Sirt7, are recently discovered regulatory proteins, which play
decisive roles in cellular metabolism, stress resistance, and proliferation. Sirtuins are …