Besides its established function in erythropoiesis, erythropoietin (EPO) is currently also
appreciated for its neuroprotective effects. The detrimental sequelae of prolonged cerebral …

The tissue protective functions of the hematopoietic growth factor erythropoietin (EPO) are
independent of its action on erythropoiesis. EPO and its receptors (EPOR) are expressed in …

This study was designed to investigate the neuroprotective effect of intrinsic and extrinsic
erythropoietin (EPO) against hypoxia/ischemia, and determine the optimal time‐window with …

Purpose: To provide an overview of the current knowledge on neuroprotective properties of
Erythropoietin (Epo), mechanisms by which Epo produces neuroprotection, and signaling …

Background and Purpose—Erythropoietin (EPO) confers potent neuroprotection against
ischemic injury. However, treatment for stroke requires high doses and multiple …

The oxygen-dependent, renal cytokine eythropoietin (Epo) is well known to increase red cell
production. Binding of Epo to the Epo receptor (EpoR) represses apoptosis of erythroid …

Apart from its hematopoietic function, erythropoietin (Epo) exerts neuroprotective functions in
brain hypoxia and ischemia. To examine the mechanisms mediating Epo's neuroprotective …

In the 10 years since neurotrophic activity was first reported for erythropoietin (EPO), a broad
understanding of its multiple paracrine/autocrine functions has emerged. Recent studies …

Multi-tissue erythropoietin receptor (EPO-R) expression provides for erythropoietin (EPO)
activity beyond its known regulation of red blood cell production. This review highlights the …

Erythropoietin (EPO) promotes neuronal survival after hypoxia and other metabolic insults
by largely unknown mechanisms. Apoptosis and necrosis have been proposed as …