Background: Ketoprofen, a potent anti-inflammatory, analgesic and anti-pyretic drug
belonging to the propionic acid class was synthesized in 1968. Rapid absorption, simple …

The aim of this work was to design, synthesize and characterize the potential anti-
nociceptive and anti-inflammatory activities of a new series of bioisosteres and hybrids from …

Background Aryl-propionic acid derivatives with ibuprofen as representative drug are very
important for therapy, being recommended especially for anti-inflammatory and analgesic …

Benzimidazole is an important pharmacophore for clinically active drugs against
inflammation and treatment of pain, however, it is associated with gastrointestinal side …

Inflammation forms the part of various diseased conditions. To treat inflammation variety of
anti inflammatory agents are synthesized, they showed undesirable side effects. In order to …

The emphasis of present research work is to improve solubility behavior of NSAID by
different water insoluble amino acid conjugation and to overcome general side effects of …

Glycolamide esters of ibuprofen (I), namely, unsubstituted (II), N, N dimethyl (III), and N, N
diethyl (IV), were synthesized and studied for different physicochemical, pharmacological …

A series of amides of ibuprofen with heteroaromatic amines was synthesized and assayed in
vivo for their analgesic properties by means of writhing test in rats. When compared to parent …

The indoles bearing a tosyl group at N-1 and a dipeptide substituent at C-3 were screened
for anti-inflammatory and anti-hyperalgesic activities. Some of the compounds made …

Synthesis of novel conjugates of the non-steroidal anti-inflammatory drug–ibuprofen with
nontoxic oligo (3-hydroxybutyrate)(OHB) is described. Presented results indicate that …