Neural stem cell (NSC) transplantation exerts a therapeutic effect on spinal cord injury (SCI)
but is limited to an unregulated differentiation pattern by which NSCs preferentially …

There are currently no effective treatments for moderate-to-severe traumatic brain injuries
(TBIs). The paracrine functions of undifferentiated neural stem cells (NSCs) are believed to …

After injury to the mammalian central nervous system (CNS), neurons are not able to
regenerate their axons and recovery is limited by restricted plasticity. Axon regeneration is …

The first thalamocortical axons to arrive in the developing cerebral cortex traverse a pathway
that is separate from the adjacent intracortical pathway for early efferents, suggesting that …

It is well established that axonal regeneration in the adult CNS is largely unsuccessful.
Numerous axon‐inhibitory molecules are now known to be present in the injured CNS, and …

Mouse embryonic stem (mES) cells express a low sulfated form of heparan sulfate (HS). HS
chains displayed by ES cells and their progeny become more complex and more sulfated …

Remyelination is the generation of new myelin sheaths after injury facilitated by processes of
differentiating oligodendrocyte precursor cells (OPCs). Although this repair phenomenon …

Objective: Failure of remyelination is a critical impediment to recovery in multiple sclerosis
(MS). Chondroitin sulfate proteoglycans (CSPGs) have been reported to accumulate in MS …

Recently we have shown that biglycan, a small chondroitin sulphate proteoglycan of the
extracellular matrix, supports the survival of cultured neurons from the developing neocortex …

Chondroitin sulfate proteoglycans (CSPGs) are upregulated in insults to the central nervous
system, including multiple sclerosis (MS), an inflammatory demyelinating condition of the …