Introduction: Sepsis refers to the host's deleterious and non-resolving systemic inflammatory
response to microbial infections and represents the leading cause of death in the intensive …

Sepsis refers to a systemic inflammatory response syndrome resulting from a microbial
infection. The inflammatory response is partly mediated by innate immune cells (such as …

Morbidity and mortality from severe sepsis remain high, despite decades of research and
improvements in intensive care unit (ICU) care. There have been over 100 failed clinical …

Sepsis remains a common cause of death in intensive care units, accounting for
approximately 20% of total deaths worldwide. Its pathogenesis is partly attributable to …

Despite recent advances in antibiotic therapy and intensive care, sepsis remains the most
common cause of death in the intensive care units, claiming approximately 225 000 victims …

Sepsis refers to a systemic inflammatory response syndrome resulting from a microbial
infection. The inflammatory response is partly mediated by innate immune cells (such as …

Sepsis remains a significant health burden and a major clinical need exists for therapeutics
to dampen the excessive and uncontrolled immune activation. Nuclear protein high mobility …

In response to infection or injury, a ubiquitous nucleosomal protein, HMGB1 is secreted
actively by innate immune cells, and/or released passively by injured/damaged cells …

Overwhelming gram‐negative bacterial infection and life‐threatening systemic inflammation
are widespread problems in critically ill emergency department patients. Currently, the …

High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that is present in almost
all cells and regulates the activity of innate immune responses in both intracellular and …