Functionalized α-amino acid building blocks have been prepared in good yield with high
regiocontrol and preservation of stereochemistry via iridium-catalyzed borylation of suitably …

Maleimide is widely applied in many fields, especially in antibody–drug conjugations and
peptide drugs. Herein, we develop a strategy for the C–H alkenylation of tryptophan and …

Reactions based on transition metals have found wide use in organic synthesis, in particular
for the functionalization of small molecules,. However, there are very few reports of using …

We report our investigation of the utility of peptide crosslinking cytochrome P450 enzymes
from biarylitide biosynthesis to generate a range of cyclic tripeptides from simple synthons …

Peptide macrocycles often display diverse bioactivities and self-assembly properties, which
lead to a variety of applications in medicinal and material sciences. Transition metal …

Heterobifunctional protein fusions are gaining interest as next-generation
biopharmaceuticals.[1–5] Combining proteins with disparate functions can enable multidrug …

Highlights•Advances in transition-metal-mediated peptide modification and cyclization.•
Heteroatom coupling strategies facilitate Cys, Lys, and backbone N–H arylation.• …

Natural peptides show high degrees of specificity in their biological action. However, their
therapeutical profile is severely limited by their conformational freedom and metabolic …

Protein-specific detection or imaging is important in medical diagnosis to detect protein
biomarkers, as well as in biology to investigate cellular processes. Small-molecule …

An increasing number of chemical reactions are being employed for bio‐orthogonal ligation
of detection labels to protein‐bound functional groups. Several of these strategies, however …