The Building Blocks of Antimicrobial Resistance in Pseudomonas aeruginosa: Implications for Current Resistance-Breaking Therapies

RF Langendonk, DR Neill, JL Fothergill - Frontiers in Cellular and …, 2021 - frontiersin.org
P. aeruginosa is classified as a priority one pathogen by the World Health Organisation, and
new drugs are urgently needed, due to the emergence of multidrug-resistant (MDR) strains …

Pseudomonas Aeruginosa: Arsenal of Resistance Mechanisms, Decades of Changing Resistance Profiles, and Future Antimicrobial Therapies

ME El Zowalaty, AA Al Thani, TJ Webster… - Future …, 2015 - Taylor & Francis
Antimicrobial resistance is one of the most serious public health issues facing humans since
the discovery of antimicrobial agents. The frequent, prolonged, and uncontrolled use of …

[HTML][HTML] Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies

Z Pang, R Raudonis, BR Glick, TJ Lin, Z Cheng - Biotechnology advances, 2019 - Elsevier
Pseudomonas aeruginosa is an opportunistic pathogen that is a leading cause of morbidity
and mortality in cystic fibrosis patients and immunocompromised individuals. Eradication of …

It's Not Easy Being Green: A Narrative Review on the Microbiology, Virulence and Therapeutic Prospects of Multidrug-Resistant Pseudomonas aeruginosa

P Behzadi, Z Baráth, M Gajdács - Antibiotics, 2021 - mdpi.com
Pseudomonas aeruginosa is the most frequent cause of infection among non-fermenting
Gram-negative bacteria, predominantly affecting immunocompromised patients, but its …

[HTML][HTML] Pseudomonas aeruginosa: Infections and novel approaches to treatment “Knowing the enemy” the threat of Pseudomonas aeruginosa and exploring novel …

N Sathe, P Beech, L Croft, C Suphioglu, A Kapat… - Infectious Medicine, 2023 - Elsevier
Pseudomonas aeruginosa is an aerobic Gram-negative rod-shaped bacterium with a
comparatively large genome and an impressive genetic capability allowing it to grow in a …

What Is New in the Anti–Pseudomonas aeruginosa Clinical Development Pipeline Since the 2017 WHO Alert?

S Reig, A Le Gouellec, S Bleves - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
The spread of antibiotic-resistant bacteria poses a substantial threat to morbidity and
mortality worldwide. Carbapenem-resistant Pseudomonas aeruginosa (CRPA) are …

Antibiotic resistance in Pseudomonas aeruginosa and alternative therapeutic options

M Chatterjee, CP Anju, L Biswas, VA Kumar… - International Journal of …, 2016 - Elsevier
Pseudomonas aeruginosa is a leading cause of nosocomial infections and is responsible
for∼ 10% of all hospital-acquired infections worldwide. It continues to pose a therapeutic …

[HTML][HTML] How to manage Pseudomonas aeruginosa infections

M Bassetti, A Vena, A Croxatto, E Righi, B Guery - Drugs in context, 2018 - ncbi.nlm.nih.gov
Infections with Pseudomonas aeruginosa have become a real concern in hospital-acquired
infections, especially in critically ill and immunocompromised patients. The major problem …

Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment

REW Hancock, DP Speert - Drug resistance updates, 2000 - Elsevier
Pseudomonas aeruginosa continues to be a major cause of infections in Western society, in
part because of its high intrinsic resistance to antibiotics. It has been demonstrated that this …

Combining antibiotics with antivirulence compounds can have synergistic effects and reverse selection for antibiotic resistance in Pseudomonas aeruginosa

C Rezzoagli, M Archetti, I Mignot, M Baumgartner… - PLoS …, 2020 - journals.plos.org
Antibiotics are losing efficacy due to the rapid evolution and spread of resistance.
Treatments targeting bacterial virulence factors have been considered as alternatives …