CRISPR/Cas9 system of RNA-guided genome editing is revolutionizing genetics research in
a wide spectrum of organisms. Even for the laboratory mouse, a model that has thrived …

Highlights•CRISPR-Cas9 is a powerful tool to modulate transcription in wide range of cell
types.•An expanding set of CRISPR-based transcription effectors is available.•Gene …

CRISPR–Cas9 has emerged as a powerful technology that enables ready modification of
the mammalian genome. The ability to modulate Cas9 activity can reduce off-target …

In just 3 years CRISPR genome editing has transformed biology, and its popularity and
potency continue to grow. New CRISPR effectors and rules for locating optimum targets …

Robust and cost-effective genome editing in a diverse array of cells and model organisms is
now possible thanks to the discovery of the RNA-guided endonucleases of the CRISPR-Cas …

The CRISPR-Cas9 system, naturally a defense mechanism in prokaryotes, has been
repurposed as an RNA-guided DNA targeting platform. It has been widely used for genome …

CRISPR technology is a universal tool for genome engineering that has revolutionized
biotechnology. Recently identified unique CRISPR/Cas systems, as well as re-engineered …

The expanding CRISPR-Cas9 technology is an easily accessible, programmable, and
precise gene-editing tool with numerous applications, most notably in biomedical research …

First introduced into mammalian organisms in 2013, the RNA-guided genome editing tool
CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR …

The last decade has seen the fields of molecular biology and genetics transformed by the
development of CRISPR-based gene editing technologies. These technologies were …