Quantification of apixaban's therapeutic utility in prevention of venous thromboembolism: selection of phase III trial dose
TA Leil, Y Feng, L Zhang, A Paccaly… - CliniCal …, 2010 - Wiley Online Library
A model‐based approach was used to integrate data from a phase II study in order to
provide a quantitative rationale for selecting the apixaban dosage regimen for a phase III …
provide a quantitative rationale for selecting the apixaban dosage regimen for a phase III …
Population pharmacokinetics, pharmacodynamics, and exploratory exposure–response analyses of apixaban in subjects treated for venous thromboembolism
W Byon, K Sweeney, C Frost… - CPT: pharmacometrics & …, 2017 - Wiley Online Library
Apixaban is approved for treatment of venous thromboembolism (VTE) and prevention of
recurrence. Population pharmacokinetics, pharmacokinetics–pharmacodynamics (anti‐FXa …
recurrence. Population pharmacokinetics, pharmacokinetics–pharmacodynamics (anti‐FXa …
Apixaban for extended treatment of venous thromboembolism
Background Apixaban, an oral factor Xa inhibitor that can be administered in a simple, fixed-
dose regimen, may be an option for the extended treatment of venous thromboembolism …
dose regimen, may be an option for the extended treatment of venous thromboembolism …
Apixaban: a review in venous thromboembolism
SL Greig, KP Garnock-Jones - Drugs, 2016 - Springer
Apixaban (Eliquis®) is an oral, direct factor Xa inhibitor that is available for use in the
treatment and secondary prevention of venous thromboembolism (VTE). Like other direct …
treatment and secondary prevention of venous thromboembolism (VTE). Like other direct …
The role of apixaban for venous and arterial thromboembolic disease
R Prom, SA Spinler - Annals of Pharmacotherapy, 2011 - journals.sagepub.com
Objective: To provide a comprehensive review of the pharmacology, pharmacokinetics,
pharmacodynamics, clinical trial data, adverse effects, and drug interactions of apixaban …
pharmacodynamics, clinical trial data, adverse effects, and drug interactions of apixaban …
Effectiveness and safety of apixaban versus rivaroxaban for prevention of recurrent venous thromboembolism and adverse bleeding events in patients with venous …
Background Apixaban and rivaroxaban, both direct-acting oral anticoagulants, are being
increasingly used in routine clinical practice because of their fixed dosing and favourable …
increasingly used in routine clinical practice because of their fixed dosing and favourable …
[HTML][HTML] Role of apixaban (eliquis) in the treatment and prevention of thromboembolic disease
A Budovich, O Zargarova, A Nogid - Pharmacy and Therapeutics, 2013 - ncbi.nlm.nih.gov
From the 1940s through 2010, warfarin (Coumadin, Bristol-Myers Squibb) was the only oral
anticoagulant on the market in the US for the treatment and prevention of thromboembolic …
anticoagulant on the market in the US for the treatment and prevention of thromboembolic …
Apixaban reduces hospitalizations in patients with venous thromboembolism: an analysis of the apixaban for the Initial management of pulmonary embolism and deep …
X Liu, M Johnson, J Mardekian, H Phatak… - Journal of the …, 2015 - Am Heart Assoc
Background In the Apixaban for the Initial Management of Pulmonary Embolism and Deep‐
Vein Thrombosis as First‐Line Therapy (AMPLIFY) trial, apixaban was noninferior to …
Vein Thrombosis as First‐Line Therapy (AMPLIFY) trial, apixaban was noninferior to …
Oral apixaban for the treatment of acute venous thromboembolism
Background Apixaban, an oral factor Xa inhibitor administered in fixed doses, may simplify
the treatment of venous thromboembolism. Methods In this randomized, double-blind study …
the treatment of venous thromboembolism. Methods In this randomized, double-blind study …
Comparative effectiveness and safety of apixaban versus warfarin in patients with venous thromboembolism
Purpose Compared with conventional therapy (enoxaparin followed by warfarin), the direct-
acting oral anticoagulant apixaban is thought to offer similar protection against recurrent …
acting oral anticoagulant apixaban is thought to offer similar protection against recurrent …
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