The CXC chemokine family is a pleiotropic family of cytokines that are involved in promoting
the trafficking of various leukocytes, in regulating angiogenesis and vascular remodeling …

Angiogenesis, defined as the growth of new capillaries from preexisting vessels, is a
pervasive biological phenomenon that is at the core of many physiologic and pathologic …

Fibrotic interstitial lung diseases are characterized by progressive decline in lung function
and premature death from respiratory failure. Fibrocytes are circulating bone marrow …

Fibrotic interstitial lung diseases are illnesses of unknown cause characterized by
progressive decline in lung function. Fibrocytes are bone marrow-derived, circulating …

CXC chemokine receptor 3 (CXCR3) is the receptor for the IFN-γ–inducible CXC
chemokines MIG/CXCL9, IP-10/CXCL10, and I-TAC/CXCL11. CXCR3 is expressed on …

Idiopathic pulmonary fibrosis is characterized by the accumulation of fibroblasts/
myofibroblasts and aberrant remodeling of the lung parenchyma. However, the sources of …

Pulmonary fibrosis is the end point of a chronic inflammatory process characterized by
leukocyte recruitment and activation, fibroblast proliferation, and increased extracellular …

Background Fibrocytes are a population of circulating bone-marrow-derived cells that
express surface markers for leukocytes and mesenchymal cells, and are capable of …

Rationale: The chemokine receptors CXCR3 and CCR4 have recently been described as
playing a pivotal role in the mouse model of bleomycin-induced fibrosis. Objectives: To …

Fibrocytes were first described over a decade ago as a population of cells in circulation with
fibroblast-like properties, which were involved in tissue repair. Since that time, we have …