Agonists bind with higher affinity to G protein-coupled heptahelical receptors than to
uncoupled receptors. Recombinant A1 and A3 adenosine receptors couple well to Gi/o, but …

The A 2a adenosine receptor, a member of the G protein-coupled receptor family, is
important in the regulation of dopaminergic pathways of the brain and in platelet and …

To provide new insights into the regions of the human A 1 adenosine receptor (A 1 AR)
involved in ligand binding, a series of chimeric human A 1 and rat A 1 adenosine receptors …

The A 2a adenosine receptor is a member of the G-protein coupled receptor family, and its
activation stimulates cyclic AMP production. To determine the residues which are involved in …

The objective of this study was to create constitutively active mutant human A3 adenosine
receptors (ARs) using single amino acid replacements, based on findings from other G …

To examine the importance of the nine native cysteine residues in the human A1 adenosine
receptor, each cysteine was individually mutated to both serine and alanine. Saturation …

The present study investigates the effect of varying ligand structure on the ability of agonists
to activate guanine nucleotide‐binding proteins of the Gi, Gs and Gq families via the A1 …

Abstract A 2A and A 2B adenosine receptors (ARs) are closely related G protein-coupled
receptor subtypes, which represent important (potential) drug targets. Despite their almost …

To provide insights into interactions between ligands and A2A adenosine receptors, site-
directed mutagenesis was used to test the roles of a glutamic acid residue in the first …

Ligand recognition has been extensively explored in G protein-coupled A 1, A 2A, and A 2B
adenosine receptors but not in the A 3 receptor, which is cerebroprotective and …