Estrogen-related receptor α is critical for the growth of estrogen receptor–negative breast cancer

RA Stein, C Chang, DA Kazmin, J Way, T Schroeder… - Cancer research, 2008 - AACR
Expression of estrogen-related receptor α (ERRα) has recently been shown to carry
negative prognostic significance in breast and ovarian cancers. The specific role of this …

Genome-wide identification of direct target genes implicates estrogen-related receptor α as a determinant of breast cancer heterogeneity

G Deblois, JA Hall, MC Perry, J Laganiere… - Cancer research, 2009 - AACR
Estrogen-related receptor α (ERRα) is an orphan nuclear receptor, the expression of which
correlates with negative prognosis in breast cancer. ERRα shares functional features with …

Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells

RA Stein, S Gaillard, DP McDonnell - The Journal of steroid biochemistry …, 2009 - Elsevier
Estrogen-related receptor alpha (ERRα) is an orphan member of the nuclear receptor family
of transcription factors. In addition to its function as a metabolic regulator, ERRα has been …

[HTML][HTML] Estrogen induces estrogen-related receptor α gene expression and chromatin structural changes in estrogen receptor (ER)-positive and ER-negative breast …

P Hu, HK Kinyamu, L Wang, J Martin, TK Archer… - Journal of Biological …, 2008 - ASBMB
Estrogen-related receptor α (ERRα), a member of the nuclear receptor superfamily, is
closely related to the estrogen receptors (ERα and ERβ). The ERRα gene is estrogen …

[HTML][HTML] Estrogen-related receptor α as a therapeutic target in cancer

RA Stein, DP McDonnell - Endocrine-related cancer, 2006 - erc.bioscientifica.com
The orphan receptor estrogen-related receptor α (ERRα) is a member of the nuclear
receptor superfamily of ligand-regulated transcription factors. This protein is structurally most …

[HTML][HTML] Estrogen-related receptor α1 actively antagonizes estrogen receptor-regulated transcription in MCF-7 mammary cells

RJ Kraus, EA Ariazi, ML Farrell, JE Mertz - Journal of Biological Chemistry, 2002 - ASBMB
The estrogen-related receptor α (ERRα) is an orphan member of the nuclear receptor
superfamily. We show that the major isoform of the human ERRα gene, ERRα1, can …

Estrogen-related receptor α and estrogen-related receptor γ associate with unfavorable and favorable biomarkers, respectively, in human breast cancer

EA Ariazi, GM Clark, JE Mertz - Cancer research, 2002 - AACR
The importance of estrogen-related receptors (ERRs) in human breast cancer was assessed
by comparing their mRNA profiles with established clinicopathological indicators and mRNA …

Genome-wide activity of unliganded estrogen receptor-α in breast cancer cells

L Caizzi, G Ferrero, S Cutrupi… - Proceedings of the …, 2014 - National Acad Sciences
Estrogen receptor-α (ERα) has central role in hormone-dependent breast cancer and its
ligand-induced functions have been extensively characterized. However, evidence exists …

The significance of the expression of ERRα as a potential biomarker in breast cancer

K Jarzabek, M Koda, L Kozlowski, S Sulkowski… - The Journal of steroid …, 2009 - Elsevier
It was shown the functional crosstalk between ERRα and ERα in breast cancer, however, the
biological significance of estrogen-related receptor α (ERRα) remains largely unclear …

A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells

C Williams, K Edvardsson, SA Lewandowski, A Ström… - Oncogene, 2008 - nature.com
Transcriptional effects of estrogen result from its activation of two estrogen receptor (ER)
isoforms; ERα that drives proliferation and ERβ that is antiproliferative. Expression of ERβ in …