Estrogen-related receptor α is critical for the growth of estrogen receptor–negative breast cancer
Expression of estrogen-related receptor α (ERRα) has recently been shown to carry
negative prognostic significance in breast and ovarian cancers. The specific role of this …
negative prognostic significance in breast and ovarian cancers. The specific role of this …
Genome-wide identification of direct target genes implicates estrogen-related receptor α as a determinant of breast cancer heterogeneity
G Deblois, JA Hall, MC Perry, J Laganiere… - Cancer research, 2009 - AACR
Estrogen-related receptor α (ERRα) is an orphan nuclear receptor, the expression of which
correlates with negative prognosis in breast cancer. ERRα shares functional features with …
correlates with negative prognosis in breast cancer. ERRα shares functional features with …
Estrogen-related receptor alpha induces the expression of vascular endothelial growth factor in breast cancer cells
RA Stein, S Gaillard, DP McDonnell - The Journal of steroid biochemistry …, 2009 - Elsevier
Estrogen-related receptor alpha (ERRα) is an orphan member of the nuclear receptor family
of transcription factors. In addition to its function as a metabolic regulator, ERRα has been …
of transcription factors. In addition to its function as a metabolic regulator, ERRα has been …
[HTML][HTML] Estrogen induces estrogen-related receptor α gene expression and chromatin structural changes in estrogen receptor (ER)-positive and ER-negative breast …
Estrogen-related receptor α (ERRα), a member of the nuclear receptor superfamily, is
closely related to the estrogen receptors (ERα and ERβ). The ERRα gene is estrogen …
closely related to the estrogen receptors (ERα and ERβ). The ERRα gene is estrogen …
[HTML][HTML] Estrogen-related receptor α as a therapeutic target in cancer
RA Stein, DP McDonnell - Endocrine-related cancer, 2006 - erc.bioscientifica.com
The orphan receptor estrogen-related receptor α (ERRα) is a member of the nuclear
receptor superfamily of ligand-regulated transcription factors. This protein is structurally most …
receptor superfamily of ligand-regulated transcription factors. This protein is structurally most …
[HTML][HTML] Estrogen-related receptor α1 actively antagonizes estrogen receptor-regulated transcription in MCF-7 mammary cells
RJ Kraus, EA Ariazi, ML Farrell, JE Mertz - Journal of Biological Chemistry, 2002 - ASBMB
The estrogen-related receptor α (ERRα) is an orphan member of the nuclear receptor
superfamily. We show that the major isoform of the human ERRα gene, ERRα1, can …
superfamily. We show that the major isoform of the human ERRα gene, ERRα1, can …
Estrogen-related receptor α and estrogen-related receptor γ associate with unfavorable and favorable biomarkers, respectively, in human breast cancer
EA Ariazi, GM Clark, JE Mertz - Cancer research, 2002 - AACR
The importance of estrogen-related receptors (ERRs) in human breast cancer was assessed
by comparing their mRNA profiles with established clinicopathological indicators and mRNA …
by comparing their mRNA profiles with established clinicopathological indicators and mRNA …
Genome-wide activity of unliganded estrogen receptor-α in breast cancer cells
Estrogen receptor-α (ERα) has central role in hormone-dependent breast cancer and its
ligand-induced functions have been extensively characterized. However, evidence exists …
ligand-induced functions have been extensively characterized. However, evidence exists …
The significance of the expression of ERRα as a potential biomarker in breast cancer
K Jarzabek, M Koda, L Kozlowski, S Sulkowski… - The Journal of steroid …, 2009 - Elsevier
It was shown the functional crosstalk between ERRα and ERα in breast cancer, however, the
biological significance of estrogen-related receptor α (ERRα) remains largely unclear …
biological significance of estrogen-related receptor α (ERRα) remains largely unclear …
A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells
Transcriptional effects of estrogen result from its activation of two estrogen receptor (ER)
isoforms; ERα that drives proliferation and ERβ that is antiproliferative. Expression of ERβ in …
isoforms; ERα that drives proliferation and ERβ that is antiproliferative. Expression of ERβ in …