Normal" healthy" aging is defined as aging without disease. Many aged people do not
exhibit symptoms of disease and lead normal lives, but nonetheless display pathological …

The brain undergoes many gross and histopathologic changes with advancing age. Some of
the changes are attributable to the aging process itself while others are manifestations of …

Human studies are reviewed concerning whether “aging”-related mechanisms contribute to
Alzheimer's disease (AD) pathogenesis. AD is defined by specific neuropathology: neuritic …

The number of people with dementia worldwide is predicted to increase to 131.5 million by
2050. When studying dementia, understanding the basis of the neuropathological …

In the last 20 years, there have been tremendous strides made in the understanding of the
molecular and cellular processes that occur during brain aging, as well as our …

The degenerative diseases of the central nervous system are characterized by a selective
loss of neurons. In this section of Current Opinion in Neurology we review examples of only …

Age is the largest risk factor for the development and progression of Parkinson's disease
(PD). Ageing affects many cellular processes that predispose to neurodegeneration, and …

The association of dementia-related pathologies with cognition is hypothesized to decrease
as age advances. We examined this in 413 persons without cognitive impairment at …

For many of us, as for the melancholy Jaques, the prospect of aging continues to conjure
images of inexorable, devastating decline, a slow march toward mindlessness and mortality …

The Douglas Mental Health University Institute, in collaboration with the McGill Centre for
Studies in Aging, organized a 2-day symposium entitled “Biological Changes Associated …