Background Artemisinin-based combinations are recommended for treatment of
uncomplicated falciparum malaria, but are costly and in limited supply. Clindamycin plus …

The resistance of Plasmodium falciparum to the chloroquine–proguanil association (C/P) as
antimalarial chemoprophylaxis is becoming increasingly common in Africa. Daily oral …

Lincomycin and clindamycin are the only members of the relatively small lincosamide
antimicrobial class marketed for use in humans. This paper only reviews data regarding …

Malaria is a significant cause of morbidity and mortality in the developing world. Until
recently malaria was winning but with increase in funding particularly from philanthropic …

Failures of malaria chemoprophylaxis have been related to a lack of compliance with
doxycycline due to its short elimination half-life. Adding a molecule with a long half-life to …

The 16-membered macrolide antibiotics (eg tylosin A and josamycin) are mainly used in
veterinary medicine, and are much less studied than their 14-and 15-membered …

Macrolide antibiotics have proven to be valuable alternatives to penicillins and
cephalosporins for the treatment of a number of infections. Currently, a number of …

Infection with Toxoplasma gondii is the most common parasitic infection worldwide with an
estimated prevalence of 1–2 billion people. The risk of developing severe toxoplasmosis is …

Myxobacteria are Gram-negative soil-dwelling bacteria belonging to the phylum
Proteobacteria. They are a rich source of promising compounds for clinical application, such …

Two of the most significant changes in the field of infectious disease management during the
last few decades are the emergence of atypical and/or new pathogens that may have …