Abstract According to the World Health Organization (WHO), Plasmodium falciparum malaria
during pregnancy is responsible for deleterious consequences for the mother and her child …

Malaria continues to be a potentially fatal threat to almost half of the world's population. In
light of this threat, the armory to fight this disease is rather limited. Resistance against the …

Renewed global efforts toward malaria eradication have highlighted the need for novel
antimalarial agents with activity against multiple stages of the parasite life cycle. We have …

Objectives Indolone-N-oxides are characterized by the presence of a highly reactive
pharmacophore, the nitrone moiety (C= N+-O−), which undergoes oxidation-reduction …

Alternative drugs to chloroquine are required to prevent the deleterious effects of malaria in
pregnancy. Fear of potential toxicity has limited antimalarial drug use in pregnancy. Animal …

Introduction: Malaria remains one of the most important infectious diseases, causing around
655 000 deaths annually, mostly among children in Sub-Saharan Africa. Plasmodium …

Over the last 15 years, the majority of malaria drug discovery and development efforts have
focused on new molecules and regimens to treat patients with uncomplicated or severe …

Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

The last two decades have seen a surge in antimalarial drug development with product
development partnerships taking a leading role. Resistance of Plasmodium falciparum to the …

Publisher Summary This chapter focuses on the new therapies for malaria. Malaria is one of
the world's most deadly diseases that threatens 40% of the world's population and infects …