In long-term bone marrow cultures, stroma-adherent progenitors proliferate significantly less
than nonadherent progenitors. Thus, close progenitor-stroma interactions may serve to …

Hematopoiesis is regulated by two sets of signals, those generated by cytokines and those
generated when precursor cells interact with bone marrow (BM) stroma. The intimate contact …

The first step in the homing of hematopoietic progenitor cells (HPCs) from the peripheral
blood to the bone marrow involves an adhesion molecule-dependent contact with human …

We have reviewed some aspects of the production, distribution, and organization of
fibronectin in the bone marrow ECM and discussed HSC-fibronectin interactions. Many …

In the bone marrow, erythropoiesis occurs in distinct anatomic units called erythroblastic
islands that consist of a central macrophage surrounded by a ring of developing …

Adhesive interactions with the extracellular matrix of the bone marrow (BM) stroma are of
critical importance in the regulation of hematopoiesis. In part, these interactions are …

P-selectin was shown to bind committed human hematopoietic progenitors (colony-forming
unit-granulocyte-macrophage [CFU-GM] and burst-forming unit-erythroid [BFU-E]) as …

One of the mechanisms by which normal hematopoietic progenitor cells remain localized
within the bone marrow microenvironment is likely to involve adhesion of these cells to …

Local regulation of hematopoietic differentiation in the marrow requires close interactions
with components of the microenvironment. In this study, we explored the capacity of human …

We explored the expression of a lymphocyte homing-associated cell adhesion molecule (H-
CAM, CD44) on hematopoietic progenitors. We demonstrate that immature myeloid and …