The growth and differentiation of hematopoietic stem cells are highly dependent on
regulatory molecules produced by stromal cells of the marrow environment. Evidence has …

There is substantial evidence that the haematopoietic microenvironment is crucial to the
growth and differentiation of haematopoietic cells. This microenvironment is composed of …

In this report we examined the expression of several adhesion molecules on human
hematopoietic progenitor cells at different maturational stages. Human hematopoietic …

Primitive clonogenic progenitor cells in human bone marrow bind to preformed marrow-
derived stromal layers in vitro and generate colonies of blast cells. The binding interaction …

The molecular basis and functional significance of interactions between haemopoietic
progenitor cells and the stromal microenvironment is still poorly understood. Here we …

A diverse system of adhesion molecules and adhesion receptors participates in
orchestrating vital biologic phenomena, such as embryogenesis, cell growth and …

It is largely unknown how hematopoietic progenitors are positioned within specialized
niches of the bone marrow microenvironment during development. Chemokines such as …

Hematopoietic microenvironment is comprised of an admixture of several adherent cell
types including fibroblasts, reticular adventitial cells, and marcophages. The biologic …

We have utilized two well-characterized human leukemia/lymphoma (LL) cell lines, UTMB-
460 and CEM, to determine the role of integrin very late antigen-alpha 4 beta 1 (VLA-4) and …

Cell adhesion molecules (CAMs) play a key role in interactions between stromal and
hematopoietic cells in bone marrow (BM) and in cell traffic through vascular endothelium. To …