[HTML][HTML] Overview and historical perspective of four papers presented on research related to the endogenous opioid system
MJ Kreek - Drug and alcohol dependence, 2010 - ncbi.nlm.nih.gov
The endogenous opioid system is now known to play a major role in many aspects of normal
physiology and neurobiology, as well as a central role in many of the addictive disease …
physiology and neurobiology, as well as a central role in many of the addictive disease …
Opioid receptors: some perspectives from early studies of their role in normal physiology, stress responsivity, and in specific addictive diseases
MJ Kreek - Neurochemical research, 1996 - Springer
The early history of research on the possible existence of specific opioid receptors and on
developing a new form of pharmacotherapy for the treatment of heroin addiction in New York …
developing a new form of pharmacotherapy for the treatment of heroin addiction in New York …
The endogenous opioidergic systems
EM Unterwald, RS Zukin - Opioids, Bulimia, and Alcohol Abuse & …, 1990 - Springer
Although opiates have been used for medicinal and recreational purposes for many
centuries, the mechanism through which they produce their effects has only been elucidated …
centuries, the mechanism through which they produce their effects has only been elucidated …
The evolution of concepts of opioid receptors
WR Martin - The opiate receptors, 1988 - Springer
The early evolution of concepts of endogenous opioids and multiple opioid receptors had its
inception in a concerted program to develop safe, nonaddicting substitutes for opiates (see …
inception in a concerted program to develop safe, nonaddicting substitutes for opiates (see …
[引用][C] Recent studies on opioid receptors: heterogeneity and purification
EJ Simon - Annals of the New York Academy of Sciences, 1986 - Wiley Online Library
This paper will review some of the more recent developments in the study of opioid
receptors. It will be a general review with emphasis on the research performed in our own …
receptors. It will be a general review with emphasis on the research performed in our own …
[HTML][HTML] Novel biochemical determinants in the preclinical evaluation of opiates
F Medzihradsky - NIDA Res Monogr, 1987 - books.google.com
Research in the field of opioid receptors has received major impetus by the identification of
ligands with high selectivity toward receptor types, eg, mu (sufentanil, DAGO), kappa (U50 …
ligands with high selectivity toward receptor types, eg, mu (sufentanil, DAGO), kappa (U50 …
[PDF][PDF] Effects of opiates, opioid antagonists and cocaine on the endogenous opioid system: clinical and laboratory studies
MJ Kreek - NIDA Res Monogr, 1992 - researchgate.net
The very exciting, independent and original reports in 1973 of Snyder, Simon and Terenius
which constituted the final discovery and delineation of specific opiate receptors, after early …
which constituted the final discovery and delineation of specific opiate receptors, after early …
22 Endogenous Opioids and Addiction
A Herz¹, R Spanagel - Pharmacology of Opioid Peptides, 1995 - books.google.com
Opioids, such as morphine and heroin, represent prototypic addictive drugs. Despite major
research efforts, the biological mechanisms underlying the addictive properties of these …
research efforts, the biological mechanisms underlying the addictive properties of these …
Endogenous and Exogenous Opioids: Role in Substance Use Disorders
L Acree - Endogenous Opioids: From Basic Science to …, 2024 - Springer
Opioid use disorders have become an epidemic in recent years with rates nearly
quadrupling since 1999 according to the US Centers for Disease Control and Prevention …
quadrupling since 1999 according to the US Centers for Disease Control and Prevention …
[HTML][HTML] Health consequences associated with the use of methadone
MJ Kreek - Research on the treatment of narcotic addiction, State …, 1983 - books.google.com
The acute effects of any opioid in a naive individual are significantly different from chronic
effects of opioids, since during chronic usage of any opioid, tolerance develops to most, but …
effects of opioids, since during chronic usage of any opioid, tolerance develops to most, but …