Adenosine receptors (ARs) function in the body's response to conditions of pathology and
stress associated with a functional imbalance, such as in the supply and demand of …

Adenosine receptors (ARs) are a four-member subfamily of G protein-coupled receptors and
are major targets of caffeine and theophylline. There are four subtypes of ARs, designated …

Adenosine is a purine nucleoside, responsible for the regulation of a wide range of
physiological and pathophysiological conditions by binding with four G-protein-coupled …

Adenosine is a physiological nucleoside which acts as an autocoid and activates G protein-
coupled membrane receptors, designated A1, A2A, A2B and A3. Adenosine plays an …

Background: Adenosine is an endogenous purine nucleoside, which mediates a variety of
important biological processes and diseases, such as vasodilation, inflammation, cancer …

Adenosine signalling has long been a target for drug development, with adenosine itself or
its derivatives being used clinically since the 1940s. In addition, methylxanthines such as …

Adenosine acts as a cytoprotective modulator in response to stress to an organ or tissue.
Although short-lived in the circulation, it can activate four subtypes of G protein-coupled …

Background: The challenges in developing any A1 adenosine receptor (A1-AdoR) agonist
involve having the desired effect on target tissue while avoiding side effects due to activation …

The purine nucleoside adenosine is consensually identified as a major local regulator of
tissue function especially when energy supply fails to meet cellular energy demand. Due to …

Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …