Depression is a global public health issue that is widely studied due to the large number of
people it affects and its serious consequences. Clinical studies have shown that regular tea …

Abstract Epigallocatechin 3-gallate (EGCG) is a natural polyphenolic antioxidant in green
tea leaves with well-known health-promoting properties. However, the influence of EGCG on …

Background Depression is a common mental illness characterised by abnormal and
depressed emotions. Total paeony glycoside (TPG) is a naturally active saponin extracted …

Scope In this study, it has been investigated whether the neuroprotective efficacy of
epigallocatechin‐3‐gallate (EGCG) is mediated by inhibition of canonical and noncanonical …

Inflammation plays a key role in the pathogenesis of depression and antidepressant
therapies. Astragalin (AST) is a bioactive flavonoid that possesses an anti-inflammatory …

Cognitive dysfunction was a common symptom of major depressive disorder (MDD). In
previous studies, psychological stress leads to activation and proliferation of microglial cells …

Major depressive disorder is a common but devastating mental disorder, and recent
evidence shows that neuroinflammation may play a pivotal role in the etiology of depression …

Background Major depressive disorder is a serious psychiatric illness having serious
damaging effect on the quality of life of suffers. Quercetin is a plant flavonoid, mostly used as …

In our study, a chronic unpredictable mild stress-induced depression rat model was
constructed then the antidepressant effects and mechanisms of Epigallocatechin-3-O-gallate …

Current evidence supports that depression is accompanied by the activation of the
inflammatory-response system, and overproduction of pro-inflammatory cytokines may play …