The long-used antibiotic fosfomycin has recently been re-evaluated as a potential regimen
for treating extended-spectrum β-lactamases (ESBLs) and carbapenem-resistant …

Antimicrobial resistance is one of the major threats to the health and welfare of both humans
and animals. The shortage of new antimicrobial agents has led to the re‐evaluation of old …

FosA, a glutathione S-transferase that inactivates fosfomycin, has been reported as the
cause of enzymatic resistance to fosfomycin. We show that multiple lineages of FosA …

Objectives Fosfomycin is an important antibiotic for the treatment of MDR
Enterobacteriaceae infections. High susceptibility rates are, however, threatened by the …

Objectives Fosfomycin is a first-line treatment for uncomplicated urinary tract infections
(UTIs) in several European countries, and it is increasingly becoming the treatment of choice …

Background fosA3 is the most commonly reported plasmid-mediated fosfomycin resistance
gene among Enterobacteriaceae. Objectives To identify the origin of fosA3. Methods The …

Fosfomycin is a decades-old antibiotic which is being revisited because of its perceived
activity against many extensively drug-resistant Gram-negative pathogens. FosA proteins …

Two hundred and thirty-three nonduplicated clinical isolates of carbapenem-resistant
Enterobacteriaceae were collected from four hospitals in Zhejiang, China. 45.1%(105/233) …

Antimicrobial resistance is well-known to be a global health and development threat. Due to
the decrease of effective antimicrobials, re-evaluation in clinical practice of old antibiotics, as …

Fosfomycin resistance in Escherichia coli is rare in the United States. An extended-spectrum
β-lactamase–producing E. coli clinical strain identified in Pennsylvania, USA, showed high …